Compile Data Set for Download or QSAR
Found 43 Enz. Inhib. hit(s) with all data for entry = 50044023
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Show SMILES O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000523(CHEMBL544784)
Show SMILES O=c1n(cc2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m1./s1
Affinity DataKi:  0.160nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000453(CHEMBL540055)
Show SMILES COc1cccc2c1ccn([C@@H]1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C17H20N2O2.ClH/c1-21-16-4-2-3-14-13(16)7-10-19(17(14)20)15-11-18-8-5-12(15)6-9-18;/h2-4,7,10,12,15H,5-6,8-9,11H2,1H3;1H/t15-;/m1./s1
Affinity DataKi:  0.160nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000471(CHEMBL542900)
Show SMILES CCc1cccc2c1ccn([C@@H]1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C18H22N2O.ClH/c1-2-13-4-3-5-16-15(13)8-11-20(18(16)21)17-12-19-9-6-14(17)7-10-19;/h3-5,8,11,14,17H,2,6-7,9-10,12H2,1H3;1H/t17-;/m1./s1
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000457(CHEMBL542904)
Show SMILES CCc1cccc2C(=O)N(CCc12)C1CN2CCC1CC2
Show InChI InChI=1S/C18H24N2O.ClH/c1-2-13-4-3-5-16-15(13)8-11-20(18(16)21)17-12-19-9-6-14(17)7-10-19;/h3-5,14,17H,2,6-12H2,1H3;1H
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000450(CHEMBL542669)
Show SMILES COc1cccc2C(=O)N(CCc12)C1CN2CCC1CC2
Show InChI InChI=1S/C17H22N2O2.ClH/c1-21-16-4-2-3-14-13(16)7-10-19(17(14)20)15-11-18-8-5-12(15)6-9-18;/h2-4,12,15H,5-11H2,1H3;1H
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m1/s1
Affinity DataKi:  0.25nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000460(CHEMBL540057)
Show SMILES O=C1N(C[C@@H]2CCCc3cccc1c23)C1CN2CCC1CC2
Show InChI InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17?;/m0./s1
Affinity DataKi:  0.320nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000475(CHEMBL555068)
Show SMILES Cc1cccc2C(=O)N(CCc12)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H22N2O.ClH/c1-12-3-2-4-15-14(12)7-10-19(17(15)20)16-11-18-8-5-13(16)6-9-18;/h2-4,13,16H,5-11H2,1H3;1H/t16-;/m1./s1
Affinity DataKi:  0.320nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000469(CHEMBL542903)
Show SMILES O=c1n(cc2CCCCc3cccc1c23)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C20H24N2O.ClH/c23-20-17-7-3-6-15-4-1-2-5-16(19(15)17)12-22(20)18-13-21-10-8-14(18)9-11-21;/h3,6-7,12,14,18H,1-2,4-5,8-11,13H2;1H/t18-;/m1./s1
Affinity DataKi:  0.400nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000455(CHEMBL2093898)
Show SMILES Cn1cc(C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C17H21N3O.ClH/c1-19-10-14(13-4-2-3-5-16(13)19)17(21)18-15-11-20-8-6-12(15)7-9-20;/h2-5,10,12,15H,6-9,11H2,1H3,(H,18,21);1H/t15-;/m1./s1
Affinity DataKi:  0.400nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000445(CHEMBL555038)
Show SMILES Cc1cccc2c1ccn(C1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C17H20N2O.ClH/c1-12-3-2-4-15-14(12)7-10-19(17(15)20)16-11-18-8-5-13(16)6-9-18;/h2-4,7,10,13,16H,5-6,8-9,11H2,1H3;1H
Affinity DataKi:  0.630nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000462(CHEMBL545719)
Show SMILES O=c1n(cc2CCc3cccc1c23)C1CN2CCC1CC2
Show InChI InChI=1S/C18H20N2O.ClH/c21-18-15-3-1-2-13-4-5-14(17(13)15)10-20(18)16-11-19-8-6-12(16)7-9-19;/h1-3,10,12,16H,4-9,11H2;1H
Affinity DataKi:  0.630nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50449636(BRL-43694 | GRANISETRON | Kytril | LY-278584 | San...)
Show SMILES CN1[C@H]2CCC[C@@H]1C[C@H](C2)NC(=O)c1nn(C)c2ccccc12
Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13-,14+
Affinity DataKi:  0.790nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000446(CHEMBL88565)
Show SMILES CN1C2CCC1CC(C2)n1cc2CCCc3cccc(c23)c1=O
Show InChI InChI=1S/C20H24N2O/c1-21-15-8-9-16(21)11-17(10-15)22-12-14-6-2-4-13-5-3-7-18(19(13)14)20(22)23/h3,5,7,12,15-17H,2,4,6,8-11H2,1H3
Affinity DataKi:  0.790nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000468(CHEMBL539020)
Show SMILES Cc1cccc2c1c(C)cn(C1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C18H22N2O.ClH/c1-12-4-3-5-15-17(12)13(2)10-20(18(15)21)16-11-19-8-6-14(16)7-9-19;/h3-5,10,14,16H,6-9,11H2,1-2H3;1H
Affinity DataKi:  1nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000472(CHEMBL555199)
Show SMILES Cn1cc(C(=O)NC2CN3CCC2CC3)c2ccccc12
Show InChI InChI=1S/C17H21N3O.ClH/c1-19-10-14(13-4-2-3-5-16(13)19)17(21)18-15-11-20-8-6-12(15)7-9-20;/h2-5,10,12,15H,6-9,11H2,1H3,(H,18,21);1H
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000466(CHEMBL540040)
Show SMILES O=c1n(cc(-c2ccccc2)c2ccccc12)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C22H22N2O.ClH/c25-22-19-9-5-4-8-18(19)20(16-6-2-1-3-7-16)14-24(22)21-15-23-12-10-17(21)11-13-23;/h1-9,14,17,21H,10-13,15H2;1H/t21-;/m1./s1
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000467(CHEMBL544785)
Show SMILES O=C(NC1CN2CCC1CC2)c1c2CCCCn2c2ccccc12
Show InChI InChI=1S/C20H25N3O.ClH/c24-20(21-16-13-22-11-8-14(16)9-12-22)19-15-5-1-2-6-17(15)23-10-4-3-7-18(19)23;/h1-2,5-6,14,16H,3-4,7-13H2,(H,21,24);1H
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000449(CHEMBL545717)
Show SMILES O=C1N(C[C@H]2CCCc3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17+;/m1./s1
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000454(CHEMBL540568)
Show SMILES COc1cccc2c1ccn(C1CC3CCC(C1)N3C)c2=O
Show InChI InChI=1S/C18H22N2O2.ClH/c1-19-12-6-7-13(19)11-14(10-12)20-9-8-15-16(18(20)21)4-3-5-17(15)22-2;/h3-5,8-9,12-14H,6-7,10-11H2,1-2H3;1H
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000459(CHEMBL553733)
Show SMILES Clc1cccc2c1ccn([C@@H]1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C16H17ClN2O.ClH/c17-14-3-1-2-13-12(14)6-9-19(16(13)20)15-10-18-7-4-11(15)5-8-18;/h1-3,6,9,11,15H,4-5,7-8,10H2;1H/t15-;/m1./s1
Affinity DataKi:  2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50031475(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
Affinity DataKi:  3.20nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
Affinity DataKi:  3.20nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000464(CHEMBL540820)
Show SMILES O=c1n(ccc2ccccc12)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H18N2O.ClH/c19-16-14-4-2-1-3-12(14)7-10-18(16)15-11-17-8-5-13(15)6-9-17;/h1-4,7,10,13,15H,5-6,8-9,11H2;1H/t15-;/m1./s1
Affinity DataKi:  4nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000476(CHEMBL543136)
Show SMILES O=C1N(C[C@@H]2CCCc3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m0./s1
Affinity DataKi:  4nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000448(CHEMBL315518)
Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1c2CCCCCn2c2ccccc12
Show InChI InChI=1S/C21H27N3O/c25-21(22-17-14-23-12-9-15(17)10-13-23)20-16-6-3-4-7-18(16)24-11-5-1-2-8-19(20)24/h3-4,6-7,15,17H,1-2,5,8-14H2,(H,22,25)/t17-/m1/s1
Affinity DataKi:  5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000456(CHEMBL555582)
Show SMILES CCCc1cn([C@@H]2CN3CCC2CC3)c(=O)c2ccccc12
Show InChI InChI=1S/C19H24N2O.ClH/c1-2-5-15-12-21(18-13-20-10-8-14(18)9-11-20)19(22)17-7-4-3-6-16(15)17;/h3-4,6-7,12,14,18H,2,5,8-11,13H2,1H3;1H/t18-;/m1./s1
Affinity DataKi:  5nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000530(CHEMBL540547)
Show SMILES O=c1n(cc2CCCc3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m0./s1
Affinity DataKi:  7.90nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000500(CHEMBL539275)
Show SMILES COc1cccc2C(=O)N(CCc12)C1CC2CCC(C1)N2C
Show InChI InChI=1S/C18H24N2O2.ClH/c1-19-12-6-7-13(19)11-14(10-12)20-9-8-15-16(18(20)21)4-3-5-17(15)22-2;/h3-5,12-14H,6-11H2,1-2H3;1H
Affinity DataKi:  10nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000461(CHEMBL539785)
Show SMILES O=C1N(CCc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1S/C16H20N2O.ClH/c19-16-14-4-2-1-3-12(14)7-10-18(16)15-11-17-8-5-13(15)6-9-17;/h1-4,13,15H,5-11H2;1H
Affinity DataKi:  10nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000452(CHEMBL554341)
Show SMILES O=c1n(ccc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1S/C16H18N2O.ClH/c19-16-14-4-2-1-3-12(14)7-10-18(16)15-11-17-8-5-13(15)6-9-17;/h1-4,7,10,13,15H,5-6,8-9,11H2;1H
Affinity DataKi:  10nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000458(CHEMBL554259)
Show SMILES COc1ccc2c3c(CCCc13)cn([C@@H]1CN3CCC1CC3)c2=O
Show InChI InChI=1S/C20H24N2O2.ClH/c1-24-18-6-5-16-19-14(3-2-4-15(18)19)11-22(20(16)23)17-12-21-9-7-13(17)8-10-21;/h5-6,11,13,17H,2-4,7-10,12H2,1H3;1H/t17-;/m1./s1
Affinity DataKi:  13nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000529(CHEMBL540823)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1c2CCCCn2c2ccccc12
Show InChI InChI=1S/C20H25N3O.ClH/c24-20(21-16-13-22-11-8-14(16)9-12-22)19-15-5-1-2-6-17(15)23-10-4-3-7-18(19)23;/h1-2,5-6,14,16H,3-4,7-13H2,(H,21,24);1H/t16-;/m0./s1
Affinity DataKi:  13nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000463(CHEMBL541844)
Show SMILES O=c1n(cc2CCc3cccc1c23)[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H20N2O.ClH/c21-18-15-3-1-2-13-4-5-14(17(13)15)10-20(18)16-11-19-8-6-12(16)7-9-19;/h1-3,10,12,16H,4-9,11H2;1H/t16-;/m0./s1
Affinity DataKi:  25nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000447(CHEMBL538027)
Show SMILES Cc1c(C(=O)NC2CN3CCC2CC3)c2ccccc2n1C
Show InChI InChI=1S/C18H23N3O.ClH/c1-12-17(14-5-3-4-6-16(14)20(12)2)18(22)19-15-11-21-9-7-13(15)8-10-21;/h3-6,13,15H,7-11H2,1-2H3,(H,19,22);1H
Affinity DataKi:  40nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000470(CHEMBL555523)
Show SMILES Cc1cccc(C(=O)N[C@@H]2CN3CCC2CC3)c1C
Show InChI InChI=1S/C16H22N2O.ClH/c1-11-4-3-5-14(12(11)2)16(19)17-15-10-18-8-6-13(15)7-9-18;/h3-5,13,15H,6-10H2,1-2H3,(H,17,19);1H/t15-;/m1./s1
Affinity DataKi:  158nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000451(CHEMBL542668)
Show SMILES COc1ccc2CCCc3cn(C4CN5CCC4CC5)c(=O)c1c23
Show InChI InChI=1S/C20H24N2O2.ClH/c1-24-17-6-5-14-3-2-4-15-11-22(20(23)19(17)18(14)15)16-12-21-9-7-13(16)8-10-21;/h5-6,11,13,16H,2-4,7-10,12H2,1H3;1H
Affinity DataKi:  158nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000465(CHEMBL555402)
Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1cccc2CCCCc12
Show InChI InChI=1S/C18H24N2O.ClH/c21-18(19-17-12-20-10-8-14(17)9-11-20)16-7-3-5-13-4-1-2-6-15(13)16;/h3,5,7,14,17H,1-2,4,6,8-12H2,(H,19,21);1H/t17-;/m1./s1
Affinity DataKi:  200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000474(CHEMBL541843)
Show SMILES COc1cccc(C(=O)N[C@@H]2CN3CCC2CC3)c1C
Show InChI InChI=1S/C16H22N2O2.ClH/c1-11-13(4-3-5-15(11)20-2)16(19)17-14-10-18-8-6-12(14)7-9-18;/h3-5,12,14H,6-10H2,1-2H3,(H,17,19);1H/t14-;/m1./s1
Affinity DataKi:  398nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000477(CHEMBL538775)
Show SMILES CCc1cccc(C(=O)N[C@@H]2CN3CCC2CC3)c1C
Show InChI InChI=1S/C17H24N2O.ClH/c1-3-13-5-4-6-15(12(13)2)17(20)18-16-11-19-9-7-14(16)8-10-19;/h4-6,14,16H,3,7-11H2,1-2H3,(H,18,20);1H/t16-;/m1./s1
Affinity DataKi:  501nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000473(CHEMBL555080)
Show SMILES Cc1ccccc1C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C15H20N2O.ClH/c1-11-4-2-3-5-13(11)15(18)16-14-10-17-8-6-12(14)7-9-17;/h2-5,12,14H,6-10H2,1H3,(H,16,18);1H
Affinity DataKi:  631nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair