Compile Data Set for Download or QSAR
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Found 14 Enz. Inhib. hit(s) with all data for entry = 50028471
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278540(1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydronaph...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278501(2-(4-chlorophenyl)-5-(1-methyl-3-(2-(pyrrolidin-1-...)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278539((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)
Affinity DataKi:  3.30nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278541(2-(4-chlorophenyl)-6-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataKi:  77nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50211166(1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Affinity DataKi:  164nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278456(5-(5-((4-chlorobenzyloxy)methyl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50150715(4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethyla...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at MCH1R (unknown origin) by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278502((R)-7-(4-chlorophenyl)-3-(6-(3-(dimethylamino)pyrr...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at MCH1R (unknown origin) by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278457(1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-(4-phenoxy...)
Affinity DataIC50: >100nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50150711(2-Benzyl-8-(2-{1-[4-(4,5-dihydro-1H-imidazol-2-yl)...)
Affinity DataIC50:  300nMAssay Description:Antagonist activity at MCH1R (unknown origin) by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50241083(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataIC50:  1.17E+3nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278542((R)-6-(4-chlorophenyl)-3-(4-(3-hydroxypyrrolidin-1...)
Affinity DataIC50: >5.00E+3nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278611(1-[3-Methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3-...)
Affinity DataIC50:  6.20E+3nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278574(1-[3-Methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3-...)
Affinity DataIC50:  7.30E+3nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed