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Report error Found 101 Enz. Inhib. hit(s) with all data for entry = 50049249
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237435(CHEMBL4066270)
Affinity DataIC50:  0.0300nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237418(CHEMBL4061789)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237422(CHEMBL4086094)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237435(CHEMBL4066270)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237422(CHEMBL4086094)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237431(CHEMBL4063424)
Affinity DataIC50:  1nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237435(CHEMBL4066270)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237435(CHEMBL4066270)
Affinity DataIC50: <1.70nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237423(CHEMBL4104017)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237422(CHEMBL4086094)
Affinity DataIC50: <1.70nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237435(CHEMBL4066270)
Affinity DataIC50: <1.70nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237421(CHEMBL4069327)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237418(CHEMBL4061789)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237418(CHEMBL4061789)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237423(CHEMBL4104017)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50:  2.70nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  3nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237419(CHEMBL4103414)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237431(CHEMBL4063424)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237431(CHEMBL4063424)
Affinity DataIC50:  3.90nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237426(CHEMBL4091588)
Affinity DataIC50:  4nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237436(CHEMBL4086161)
Affinity DataIC50:  4nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237423(CHEMBL4104017)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237422(CHEMBL4086094)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237419(CHEMBL4103414)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237418(CHEMBL4061789)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237436(CHEMBL4086161)
Affinity DataIC50:  7nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237426(CHEMBL4091588)
Affinity DataIC50:  8nMAssay Description:Agonist activity against human melanocortin receptor hMC1R at 50% maximum cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237421(CHEMBL4069327)
Affinity DataIC50:  10nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237427(CHEMBL4104070)
Affinity DataIC50:  10nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237427(CHEMBL4104070)
Affinity DataIC50:  11nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237419(CHEMBL4103414)
Affinity DataIC50:  15nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237422(CHEMBL4086094)
Affinity DataIC50:  19nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50:  20nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237423(CHEMBL4104017)
Affinity DataIC50:  25nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237437(CHEMBL4077075)
Affinity DataIC50:  28nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237437(CHEMBL4077075)
Affinity DataIC50:  30nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  35nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237431(CHEMBL4063424)
Affinity DataIC50:  38nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237421(CHEMBL4069327)
Affinity DataIC50:  40nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237416(CHEMBL3348835)
Affinity DataIC50:  43nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237416(CHEMBL3348835)
Affinity DataIC50:  78nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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