Compile Data Set for Download or QSAR
maximum 50k data
Found 49 Enz. Inhib. hit(s) with all data for entry = 50043416
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440869(CHEMBL2431727)
Affinity DataKi:  600nMAssay Description:Displacement of [3H]2-furoyl-LIGRL-NH2 from human PAR2 expressed in human NCTC-2544 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50241049(CHEMBL463763 | Triptolide, 1 | triptolide)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human PAR2 expressed in human A549 cells assessed as inhibition of 2f-LIGRLO-NH2-induced NFkappaB activation by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50241049(CHEMBL463763 | Triptolide, 1 | triptolide)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human PAR2 expressed in human A549 cells coexpressing TACR1 assessed as inhibition of substance P-induced IL-8 production by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412718(CHEMBL509819)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]-2-furoyl-LIGRL-NH2 from human PAR2 expressed in human NCTC-2544 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440858(CHEMBL2431721)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at PAR2 in human neutrophils assessed as inhibition of chemotactic migration of cells towards trypsin/SLIGRL-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440868(CHEMBL2431617)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of agonist-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440861(CHEMBL2431719)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at human PAR2 expressed in African green monkey COS7 cells assessed as inhibition of SLIGKV-NH2-induced inositol triphosphate pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440869(CHEMBL2431727)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity at human PAR2 expressed in human NCTC-2544 cells assessed as inhibition of SLIGKV-NH2-induced NFkappaB activation preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50417178(CHEMBL1270720)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of agonist-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  3.60E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440861(CHEMBL2431719)
Affinity DataIC50:  1.50E+4nMAssay Description:Partial agonist activity at PAR2 in human SW620 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440866(CHEMBL2431619)
Affinity DataIC50:  3.40E+4nMAssay Description:Antagonist activity at PAR2 in human HCT15 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(RAT)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440871(CHEMBL2431725)
Affinity DataIC50:  5.00E+4nMAssay Description:Antagonist activity at rat PAR2 expressed in rat KNRK cells assessed as inhibition of trypsin-induced receptor activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(RAT)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440870(CHEMBL2431726)
Affinity DataIC50:  5.00E+4nMAssay Description:Antagonist activity at rat PAR2 expressed in rat KNRK cells assessed as inhibition of trypsin-induced receptor activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50329487(5-Isoxazoyl-Cha-Ile-4-aminophenyl-(4morpholin-1-yl...)
Affinity DataIC50:  5.70E+4nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of agonist-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440864(CHEMBL2431715)
Affinity DataIC50:  7.70E+4nMAssay Description:Antagonist activity at PAR2 in human HCT15 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440865(CHEMBL2431620)
Affinity DataIC50:  2.43E+5nMAssay Description:Antagonist activity at PAR2 in human HCT15 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440867(CHEMBL2431618)
Affinity DataIC50:  7.00E+5nMAssay Description:Antagonist activity at PAR2 in human HaCaT cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440875(CHEMBL236704)
Affinity DataEC50:  300nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440876(CHEMBL396183)
Affinity DataEC50:  400nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440877(CHEMBL397820)
Affinity DataEC50:  400nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440878(CHEMBL438676)
Affinity DataEC50:  700nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412718(CHEMBL509819)
Affinity DataEC50:  200nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM85517(CAS_171436-38-7 | SL-NH2 | SLIGRL-NH2)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440874(CHEMBL398131)
Affinity DataEC50:  200nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440873(CHEMBL2431723)
Affinity DataEC50:  200nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440872(CHEMBL2431724)
Affinity DataEC50:  4nMAssay Description:Agonist activity at PAR2 in human 16HBE14o- cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440872(CHEMBL2431724)
Affinity DataEC50:  10nMAssay Description:Agonist activity at PAR2 in human 16HBE14o- cells assessed as increase in MAPK levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412717(AC-55541 | CHEMBL493076)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of cell proliferation after 5 days by beta-galactosidase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412708(AC-264613 | CHEMBL494502)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of cell proliferation after 5 days by beta-galactosidase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412717(AC-55541 | CHEMBL493076)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of phosphatidylinositol hydrolysis after 45 mins by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412708(AC-264613 | CHEMBL494502)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of phosphatidylinositol hydrolysis after 45 mins by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412717(AC-55541 | CHEMBL493076)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as increase in intracellular calcium level by bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50412708(AC-264613 | CHEMBL494502)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human PAR2 expressed in HEK293T cells assessed as increase in intracellular calcium level by bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440860(CHEMBL2431720)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human PAR2 expressed in African green monkey COS7 cells assessed as stimulation of inositol triphosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440859(CHEMBL2431718)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human PAR1 expressed in African green monkey COS7 cells assessed as stimulation of inositol triphosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440859(CHEMBL2431718)
Affinity DataEC50:  8.00E+3nMAssay Description:Agonist activity at PAR2 in human platelets by platelet aggregation assay in presence of SFLLRNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440857(CHEMBL392253)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440856(CHEMBL398128)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440855(CHEMBL236293)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440854(CHEMBL236292)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440853(CHEMBL236037)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440852(CHEMBL414319)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM85517(CAS_171436-38-7 | SL-NH2 | SLIGRL-NH2)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at PAR2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440850(CHEMBL238396)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440851(CHEMBL267729)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed