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Report error Found 325 Enz. Inhib. hit(s) with all data for entry = 50009368
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcount as...More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing MgCl2 by topcount a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcou...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-citalopram from human SERT receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2B adrenergic receptor transiently expressed in HEKT cell membranes measured after 90 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  77nMAssay Description:Displacement of [125I]-pindolol from recombinant human beta1 adrenergic receptor expressed in CHO Flp-In cell membranes measured after 90 mins by mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcount as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-pyrilamine from human histamine H1 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  205nMAssay Description:Displacement of [3H]-Win35428 from human DAT expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  224nMAssay Description:Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  383nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor (unknown origin) after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  436nMAssay Description:Displacement of [3H]-Nisoxetine from human NET receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  531nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor (unknown origin) after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  666nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1B adrenergic receptor transiently expressed in HEKT cell membranes measured after 90 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  674nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  708nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor stably expressed in CHO cell membranes measured after 90 mins by microbeta scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  720nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  744nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D2 receptor stably expressed in fibroblast cell membranes measured after 90 mins by mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  745nMAssay Description:Displacement of [3H]-DAMGO from recombinant human MOR stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  762nMAssay Description:Displacement of [3H]-Mesulergine from recombinant human 5HT2C receptor expressed in HEK cell membranes measured after 90 mins by microbeta scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  770nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  893nMAssay Description:Displacement of [3H]-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK Flp-In cell membranes measured after 90 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1D adrenergic receptor measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  1.19E+3nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  1.24E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  2.11E+3nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor stably expressed in CHO cell membranes measured after 90 mins by microbeta scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  2.28E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M4 receptor expressed in stable CHO cell membranes after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M5 receptor expressed in stable CHO cell membranes after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  2.68E+3nMAssay Description:Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  2.75E+3nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) measured after 90 mins by microbeta counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]-Ketanserin from 5HT2A receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  3.51E+3nMAssay Description:Displacement of [3H]5-CT from recombinant human 5HT1B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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