Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50010062
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  20nMAssay Description:Activity at 6His-tagged human RORgamma LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of biotinylated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50: 3.80nMAssay Description:Activity at biotinylated 6His-tagged human RORgamma LBD (259 to 518 residues) assessed as induction of biotinylated SRC1 peptide recruitment incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50203506(CHEMBL3977048)
Affinity DataIC50: 7nMAssay Description:Activity at biotinylated APC-labeled human RORgamma LBD assessed as of Induction of biotinylated SRC1 peptide recruitment incubated for 1 hr by TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50: 9.40nMAssay Description:Activity at RORgamma in human PBMC assessed as induction of IL17A production after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50203506(CHEMBL3977048)
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at GAL4-fused human RORgamma expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 18hr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 20nMAssay Description:Activity at APC-labeled 6His-tagged human RORgamma LBD (263 to 518 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Displacement of [3H]T0901317 from N-6HN-MBP-Avi-TCS-tagged human RORgamma LBD (P260 to K518 residues) preincubated for 30 mins followed by ligand add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50203506(CHEMBL3977048)
Affinity DataIC50: 63nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) expressed in human Jurkat cells assessed as inhibition of IL-17F production after 20 hrs by luc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed