Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50010221
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536411(CHEMBL4564931)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536416(CHEMBL4522825)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536417(CHEMBL4592637)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536413(CHEMBL4593011)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536415(CHEMBL4582864)
Affinity DataIC50: 63nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 96nMAssay Description:Inhibition of PI3Kgamma/delta in human whole blood assessed as inhibition of FcepsilonR1/fMLP-stimulated basophil degranulation by measuring CD63+ ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3Kgamma/delta in human whole blood assessed as inhibition of FcepsilonR1/fMLP-stimulated basophil degranulation by measuring CD63+ ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536413(CHEMBL4593011)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536411(CHEMBL4564931)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 250nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 251nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536414(CHEMBL4522018)
Affinity DataIC50: 398nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 501nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 501nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 631nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholine/ethanolamine kinase(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHKB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol kinase zeta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DAGK zeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK3C2B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIP4K2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FRAP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SPHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholine kinase alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of choline kinase alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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