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Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50012287
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  75nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopyMore data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataKd:  30nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Affinity DataKd:  60nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  3nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as Kd1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataKd:  400nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in bacterial expression system by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  5.60E+3nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM23446(3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...)
Affinity DataKd:  8.10E+3nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataKd:  1.20E+4nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  278nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as Kd2 by isothermal titration calorimetryMore data for this Ligand-Target Pair