Compile Data Set for Download or QSAR
Found 56 Enz. Inhib. hit(s) with all data for entry = 50014111
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572786(CHEMBL4876215)
Show SMILES CC(=O)N1CCC(CC1)N1C[C@H]2C[C@@H](C1)c1ccc(-c3ccccc3CN3CCOCC3)c(=O)n1C2
Show InChI InChI=1S/C29H38N4O3/c1-21(34)31-10-8-25(9-11-31)32-17-22-16-24(20-32)28-7-6-27(29(35)33(28)18-22)26-5-3-2-4-23(26)19-30-12-14-36-15-13-30/h2-7,22,24-25H,8-20H2,1H3/t22-,24+/m1/s1
Affinity DataIC50: 890nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572762(CHEMBL4852059)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccncc1
Show InChI InChI=1S/C16H15N3O2S.ClH/c17-15-5-1-4-14-13(15)3-2-6-16(14)22(20,21)19-11-12-7-9-18-10-8-12;/h1-10,19H,11,17H2;1H
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572785(CHEMBL4874776)
Show SMILES NNc1nc2ccccc2nc1S
Show InChI InChI=1S/C8H8N4S/c9-12-7-8(13)11-6-4-2-1-3-5(6)10-7/h1-4H,9H2,(H,10,12)(H,11,13)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of NSD2 E1009K mutant (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572778(CHEMBL4846461)
Show SMILES Cl.Cl.CCN1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C24H29N3O2S.2ClH/c1-2-27-16-14-20(15-17-27)26-23-12-6-11-22-21(23)10-7-13-24(22)30(28,29)25-18-19-8-4-3-5-9-19;;/h3-13,20,25-26H,2,14-18H2,1H3;2*1H
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572783(CHEMBL4866486)
Show SMILES CCC(C)NC(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C19H31N7O5/c1-3-9(2)25-10(4-5-11(20)19(29)30)6-12-14(27)15(28)18(31-12)26-8-24-13-16(21)22-7-23-17(13)26/h7-12,14-15,18,25,27-28H,3-6,20H2,1-2H3,(H,29,30)(H2,21,22,23)/t9?,10?,11-,12+,14+,15+,18+/m0/s1
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of NSD2 (953 to 1240 residues) (unknown origin) using SAM as substrate in presence of nucleosome by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572766(CHEMBL4877109)
Show SMILES Cl.Cl.CN1CCC(CNS(=O)(=O)c2cccc3c(N)cccc23)CC1
Show InChI InChI=1S/C17H23N3O2S.2ClH/c1-20-10-8-13(9-11-20)12-19-23(21,22)17-7-3-4-14-15(17)5-2-6-16(14)18;;/h2-7,13,19H,8-12,18H2,1H3;2*1H
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572777(CHEMBL4858477)
Show SMILES Cl.Cl.CN1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C23H27N3O2S.2ClH/c1-26-15-13-19(14-16-26)25-22-11-5-10-21-20(22)9-6-12-23(21)29(27,28)24-17-18-7-3-2-4-8-18;;/h2-12,19,24-25H,13-17H2,1H3;2*1H
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572779(CHEMBL4851472)
Show SMILES Cl.Cl.CC(=O)N1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C24H27N3O3S.2ClH/c1-18(28)27-15-13-20(14-16-27)26-23-11-5-10-22-21(23)9-6-12-24(22)31(29,30)25-17-19-7-3-2-4-8-19;;/h2-12,20,25-26H,13-17H2,1H3;2*1H
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572776(CHEMBL4847094)
Show SMILES Cl.Cl.O=S(=O)(NCc1ccccc1)c1cccc2c(NC3CCNCC3)cccc12
Show InChI InChI=1S/C22H25N3O2S.2ClH/c26-28(27,24-16-17-6-2-1-3-7-17)22-11-5-8-19-20(22)9-4-10-21(19)25-18-12-14-23-15-13-18;;/h1-11,18,23-25H,12-16H2;2*1H
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572758(CHEMBL4877005)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O2S.ClH/c19-18(20,21)13-9-7-12(8-10-13)11-23-26(24,25)17-6-2-3-14-15(17)4-1-5-16(14)22;/h1-10,23H,11,22H2;1H
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572774(CHEMBL4857152)
Show SMILES Cl.O=S(=O)(NCc1ccccc1)c1cccc2c(NCC3CC3)cccc12
Show InChI InChI=1S/C21H22N2O2S.ClH/c24-26(25,23-15-16-6-2-1-3-7-16)21-11-5-8-18-19(21)9-4-10-20(18)22-14-17-12-13-17;/h1-11,17,22-23H,12-15H2;1H
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Show SMILES O=C([C@H]1Cc2ccccc2C(=O)O1)N1CCN(Cc2nc3sc4CCCCc4c3c(=O)[nH]2)CC1
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572782(CHEMBL4852534)
Show SMILES Cl.CS(=O)(=O)N1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C23H27N3O4S2.ClH/c1-31(27,28)26-15-13-19(14-16-26)25-22-11-5-10-21-20(22)9-6-12-23(21)32(29,30)24-17-18-7-3-2-4-8-18;/h2-12,19,24-25H,13-17H2,1H3;1H
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572775(CHEMBL4864181)
Show SMILES Cl.O=S(=O)(NCc1ccccc1)c1cccc2c(NC3CCCCC3)cccc12
Show InChI InChI=1S/C23H26N2O2S.ClH/c26-28(27,24-17-18-9-3-1-4-10-18)23-16-8-13-20-21(23)14-7-15-22(20)25-19-11-5-2-6-12-19;/h1,3-4,7-10,13-16,19,24-25H,2,5-6,11-12,17H2;1H
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572757(CHEMBL4865731)
Show SMILES Cl.COc1ccc(CNS(=O)(=O)c2cccc3c(N)cccc23)cc1
Show InChI InChI=1S/C18H18N2O3S.ClH/c1-23-14-10-8-13(9-11-14)12-20-24(21,22)18-7-3-4-15-16(18)5-2-6-17(15)19;/h2-11,20H,12,19H2,1H3;1H
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572756(CHEMBL4858012)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O2S.ClH/c18-13-9-7-12(8-10-13)11-20-23(21,22)17-6-2-3-14-15(17)4-1-5-16(14)19;/h1-10,20H,11,19H2;1H
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572755(CHEMBL4870938)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H18N2O2S.ClH/c19-17-10-4-9-16-15(17)8-5-11-18(16)23(21,22)20-13-12-14-6-2-1-3-7-14;/h1-11,20H,12-13,19H2;1H
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572780(CHEMBL4851342)
Show SMILES Cl.O=C(N1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H29N3O3S.ClH/c33-29(23-11-5-2-6-12-23)32-19-17-24(18-20-32)31-27-15-7-14-26-25(27)13-8-16-28(26)36(34,35)30-21-22-9-3-1-4-10-22;/h1-16,24,30-31H,17-21H2;1H
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572759(CHEMBL4850576)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccc(cc1)C#N
Show InChI InChI=1S/C18H15N3O2S.ClH/c19-11-13-7-9-14(10-8-13)12-21-24(22,23)18-6-2-3-15-16(18)4-1-5-17(15)20;/h1-10,21H,12,20H2;1H
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572768(CHEMBL4874995)
Show SMILES Cl.CC(C)(C)NS(=O)(=O)c1cccc2c(N)cccc12
Show InChI InChI=1S/C14H18N2O2S.ClH/c1-14(2,3)16-19(17,18)13-9-5-6-10-11(13)7-4-8-12(10)15;/h4-9,16H,15H2,1-3H3;1H
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572746(CHEMBL4875973)
Show SMILES Cl.Nc1cccc2c(cccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N2O.ClH/c19-17-11-5-8-14-15(17)9-4-10-16(14)18(21)20-12-13-6-2-1-3-7-13;/h1-11H,12,19H2,(H,20,21);1H
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572748(CHEMBL4877262)
Show SMILES O=C(NCc1ccccc1)c1cccc2ncccc12
Show InChI InChI=1S/C17H14N2O/c20-17(19-12-13-6-2-1-3-7-13)15-8-4-10-16-14(15)9-5-11-18-16/h1-11H,12H2,(H,19,20)
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572767(CHEMBL4860747)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C19H18N2O2S.ClH/c20-17-10-4-9-15-14(17)8-5-11-19(15)24(22,23)21-18-12-16(18)13-6-2-1-3-7-13;/h1-11,16,18,21H,12,20H2;1H
Affinity DataIC50: 1.99E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of DOT1L (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase 2B(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLL4 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLLI (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase SETD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572781(CHEMBL4848209)
Show SMILES Cl.O=C(OCc1ccccc1)N1CCC(CC1)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C30H31N3O4S.ClH/c34-30(37-22-24-11-5-2-6-12-24)33-19-17-25(18-20-33)32-28-15-7-14-27-26(28)13-8-16-29(27)38(35,36)31-21-23-9-3-1-4-10-23;/h1-16,25,31-32H,17-22H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572773(CHEMBL4859524)
Show SMILES Cl.CC(=O)Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C19H18N2O3S.ClH/c1-14(22)21-18-11-5-10-17-16(18)9-6-12-19(17)25(23,24)20-13-15-7-3-2-4-8-15;/h2-12,20H,13H2,1H3,(H,21,22);1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572772(CHEMBL4854792)
Show SMILES Cl.CN(C)c1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C19H20N2O2S.ClH/c1-21(2)18-12-6-11-17-16(18)10-7-13-19(17)24(22,23)20-14-15-8-4-3-5-9-15;/h3-13,20H,14H2,1-2H3;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572771(CHEMBL4863964)
Show SMILES O=S(=O)(NCc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C17H15NO2S/c19-21(20,18-13-14-7-2-1-3-8-14)17-12-6-10-15-9-4-5-11-16(15)17/h1-12,18H,13H2
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572770(CHEMBL4852581)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H24N2O2S.ClH/c23-21-10-4-9-20-19(21)8-5-11-22(20)27(25,26)24-14-12-18(13-15-24)16-17-6-2-1-3-7-17;/h1-11,18H,12-16,23H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572769(CHEMBL4848131)
Show SMILES Cl.CN(Cc1ccccc1)S(=O)(=O)c1cccc2c(N)cccc12
Show InChI InChI=1S/C18H18N2O2S.ClH/c1-20(13-14-7-3-2-4-8-14)23(21,22)18-12-6-9-15-16(18)10-5-11-17(15)19;/h2-12H,13,19H2,1H3;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572765(CHEMBL4858426)
Show SMILES Cl.Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCC1CCCNC1
Show InChI InChI=1S/C16H21N3O2S.2ClH/c17-15-7-1-6-14-13(15)5-2-8-16(14)22(20,21)19-11-12-4-3-9-18-10-12;;/h1-2,5-8,12,18-19H,3-4,9-11,17H2;2*1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572764(CHEMBL4867601)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCC1CCCCC1
Show InChI InChI=1S/C17H22N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h4-5,8-11,13,19H,1-3,6-7,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572761(CHEMBL4867190)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C18H16N2O4S.ClH/c19-16-5-1-4-15-14(16)3-2-6-17(15)25(23,24)20-11-12-7-9-13(10-8-12)18(21)22;/h1-10,20H,11,19H2,(H,21,22);1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572760(CHEMBL4872729)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1cccc(c1)C#N
Show InChI InChI=1S/C18H15N3O2S.ClH/c19-11-13-4-1-5-14(10-13)12-21-24(22,23)18-9-3-6-15-16(18)7-2-8-17(15)20;/h1-10,21H,12,20H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572754(CHEMBL4875996)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C16H14N2O2S.ClH/c17-15-10-4-9-14-13(15)8-5-11-16(14)21(19,20)18-12-6-2-1-3-7-12;/h1-11,18H,17H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572753(CHEMBL4865640)
Show SMILES Cl.Nc1ccc(c2ccccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-11-17(15-9-5-4-8-14(15)16)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572752(CHEMBL4847273)
Show SMILES Cl.Nc1ccc2cc(ccc2c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-8-6-15-11-17(9-7-14(15)10-16)22(20,21)19-12-13-4-2-1-3-5-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572751(CHEMBL4856783)
Show SMILES Cl.Nc1cccc2cc(ccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-17-8-4-7-14-11-15(9-10-16(14)17)22(20,21)19-12-13-5-2-1-3-6-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572750(CHEMBL4864770)
Show SMILES Cl.Nc1ccc2c(cccc2c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-15-9-10-16-14(11-15)7-4-8-17(16)22(20,21)19-12-13-5-2-1-3-6-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572747(CHEMBL4856393)
Show SMILES O=C(NCc1ccccc1)c1cccc2[nH]ccc12
Show InChI InChI=1S/C16H14N2O/c19-16(18-11-12-5-2-1-3-6-12)14-7-4-8-15-13(14)9-10-17-15/h1-10,17H,11H2,(H,18,19)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572784(CHEMBL1092583)
Show SMILES NC(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6?,7-,8+,10+,11+,14+/m0/s1
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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