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Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50015811
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataIC50:  0.0130nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589777(CHEMBL5192350)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589778(CHEMBL5204987)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589773(CHEMBL5188908)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589780(CHEMBL5188982)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin K(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human Cathepsin K using Ac-LR-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589779(CHEMBL5181886)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589775(CHEMBL5172248)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589774(CHEMBL5201620)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589776(CHEMBL5180494)
Affinity DataIC50:  3nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  5nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589772(CHEMBL5082224)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589771(CHEMBL5208946)
Affinity DataIC50:  8nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589781(CHEMBL5180524 | US20240092759, Compound 37)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant 6 his tagged SARS CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQYSGFRKM-E as fluorogenic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  33nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin F(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  74nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  75nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  146nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589771(CHEMBL5208946)
Affinity DataIC50:  210nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  990nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human Cathepsin B using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589772(CHEMBL5082224)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin F(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin F(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin K using Ac-LR-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589770(CHEMBL5188502)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Cathepsin K using Ac-LR-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed