Compile Data Set for Download or QSAR
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Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50018630
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50:  0.0583nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610507(CHEMBL5271975)
Affinity DataIC50:  0.100nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM249900(US10005782, Compound 27b | US9447106, 27 | US95561...)
Affinity DataIC50:  0.300nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  0.318nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  0.335nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610505(CHEMBL5290606)
Affinity DataIC50:  0.5nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.850nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50:  1nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610504(CHEMBL3892767)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50239946(CHEMBL4084368)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PD-1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610506(CHEMBL5269771)
Affinity DataIC50:  2.90nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  3nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610508(CHEMBL5273455)
Affinity DataIC50:  4nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  5nMAssay Description:Binding affinity to human ARG1 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50369719(CHEMBL4162057)
Affinity DataIC50:  5.90nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610520(CHEMBL5268100)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of SHP2 (unknown origin) E76K mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  8.5nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM291522(1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610520(CHEMBL5268100)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
TargetTransforming growth factor beta-1 proprotein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50015639(CHEMBL3260567 | USRE47141, Example 2)
Affinity DataIC50:  13nMAssay Description:Inhibition of TGF-beta receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  14nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50:  15nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50:  16nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50:  18nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50:  19nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610519(CHEMBL5269504)
Affinity DataIC50:  23nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610519(CHEMBL5269504)
Affinity DataIC50:  23nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50:  30nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50:  30nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransforming growth factor beta-1 proprotein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610513(CHEMBL5280211)
Affinity DataIC50:  38nMAssay Description:Inhibition of TGF-beta receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610517(CHEMBL5271735)
Affinity DataIC50:  47nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataIC50:  51nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransforming growth factor beta-1 proprotein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610512(CHEMBL5272606)
Affinity DataIC50:  56nMAssay Description:Inhibition of TGF-beta receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610521(CHEMBL5280755)
Affinity DataIC50:  71nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610509(CHEMBL5276302)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM36335(US10639284, Compound 1.001 | US11426364, Compound ...)
Affinity DataIC50: <100nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610518(CHEMBL5270041)
Affinity DataIC50: >100nMAssay Description:Inhibition of SHP2 (unknown origin) at 100 mg/mLMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataIC50:  270nMAssay Description:Binding affinity to human ARG1 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant human ARG2 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
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