Compile Data Set for Download or QSAR
Found 37 Enz. Inhib. hit(s) with all data for entry = 766
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5874(2-Anilino-5-aryloxazole 38 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccsc2)c1
Show InChI InChI=1S/C22H20N2O4S2/c1-3-30(25,26)18-7-8-20(27-2)19(12-18)24-22-23-13-21(28-22)16-6-4-5-15(11-16)17-9-10-29-14-17/h4-14H,3H2,1-2H3,(H,23,24)
Affinity DataIC50: 15nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5873(2-Anilino-5-aryloxazole 37 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2cccs2)c1
Show InChI InChI=1S/C22H20N2O4S2/c1-3-30(25,26)17-9-10-19(27-2)18(13-17)24-22-23-14-20(28-22)15-6-4-7-16(12-15)21-8-5-11-29-21/h4-14H,3H2,1-2H3,(H,23,24)
Affinity DataIC50: 16nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5870(2-Anilino-5-aryloxazole 33 | 4-(2-{[5-(Ethylsulfon...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(cc2)C(N)=O)c1
Show InChI InChI=1S/C19H19N3O5S/c1-3-28(24,25)14-8-9-16(26-2)15(10-14)22-19-21-11-17(27-19)12-4-6-13(7-5-12)18(20)23/h4-11H,3H2,1-2H3,(H2,20,23)(H,21,22)
Affinity DataIC50: 18nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5875(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26)
Affinity DataIC50: 22nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5862(2-Anilino-5-aryloxazole 25 | 5-(3-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(Cl)c2)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)14-7-8-16(24-2)15(10-14)21-18-20-11-17(25-18)12-5-4-6-13(19)9-12/h4-11H,3H2,1-2H3,(H,20,21)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5859(2-Anilino-5-aryloxazole 20 | N,N-Diethyl-4-methoxy...)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C20H23N3O4S/c1-4-23(5-2)28(24,25)16-11-12-18(26-3)17(13-16)22-20-21-14-19(27-20)15-9-7-6-8-10-15/h6-14H,4-5H2,1-3H3,(H,21,22)
Affinity DataIC50: 23nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5878(2-Anilino-5-aryloxazole 42 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2cncn2C)c1
Show InChI InChI=1S/C22H22N4O4S/c1-4-31(27,28)17-8-9-20(29-3)18(11-17)25-22-24-13-21(30-22)16-7-5-6-15(10-16)19-12-23-14-26(19)2/h5-14H,4H2,1-3H3,(H,24,25)
Affinity DataIC50: 25nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5871(2-Anilino-5-aryloxazole 35 | 5-(3-Ethylphenyl)-N-[...)
Show SMILES CCc1cccc(c1)-c1cnc(Nc2cc(ccc2OC)S(=O)(=O)CC)o1
Show InChI InChI=1S/C20H22N2O4S/c1-4-14-7-6-8-15(11-14)19-13-21-20(26-19)22-17-12-16(27(23,24)5-2)9-10-18(17)25-3/h6-13H,4-5H2,1-3H3,(H,21,22)
Affinity DataIC50: 29nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5864(2-Anilino-5-aryloxazole 27 | 5-(3-Methoxyphenyl)-N...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(OC)c2)c1
Show InChI InChI=1S/C19H20N2O5S/c1-4-27(22,23)15-8-9-17(25-3)16(11-15)21-19-20-12-18(26-19)13-6-5-7-14(10-13)24-2/h5-12H,4H2,1-3H3,(H,20,21)
Affinity DataIC50: 36nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM11445(2-Anilino-5-aryloxazole 46 | N-(cyclopropylmethyl)...)
Show SMILES COc1ccc(cc1Nc1ncc(o1)-c1cccc(c1)-c1cccnc1)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C25H24N4O4S/c1-32-23-10-9-21(34(30,31)28-14-17-7-8-17)13-22(23)29-25-27-16-24(33-25)19-5-2-4-18(12-19)20-6-3-11-26-15-20/h2-6,9-13,15-17,28H,7-8,14H2,1H3,(H,27,29)
Affinity DataIC50: 38nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5881(2-Anilino-5-aryloxazole 45 | 5-[3-(2-chlorophenyl)...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccc2Cl)c1
Show InChI InChI=1S/C24H21ClN2O4S/c1-3-32(28,29)18-11-12-22(30-2)21(14-18)27-24-26-15-23(31-24)17-8-6-7-16(13-17)19-9-4-5-10-20(19)25/h4-15H,3H2,1-2H3,(H,26,27)
Affinity DataIC50: 39nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5860(2-Anilino-5-aryloxazole 21 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C18H18N2O4S/c1-3-25(21,22)14-9-10-16(23-2)15(11-14)20-18-19-12-17(24-18)13-7-5-4-6-8-13/h4-12H,3H2,1-2H3,(H,19,20)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5869(2-Anilino-5-aryloxazole 32 | 4-(2-{[5-(ethanesulfo...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C19H17N3O4S/c1-3-27(23,24)15-8-9-17(25-2)16(10-15)22-19-21-12-18(26-19)14-6-4-13(11-20)5-7-14/h4-10,12H,3H2,1-2H3,(H,21,22)
Affinity DataIC50: 51nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5876(2-Anilino-5-aryloxazole 40 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2cccnc2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)19-9-10-21(29-2)20(13-19)26-23-25-15-22(30-23)17-7-4-6-16(12-17)18-8-5-11-24-14-18/h4-15H,3H2,1-2H3,(H,25,26)
Affinity DataIC50: 76nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5877(2-Anilino-5-aryloxazole 41 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccncc2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)19-7-8-21(29-2)20(14-19)26-23-25-15-22(30-23)18-6-4-5-17(13-18)16-9-11-24-12-10-16/h4-15H,3H2,1-2H3,(H,25,26)
Affinity DataIC50: 78nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5879(2-Anilino-5-aryloxazole 43 | 5-(1,1 -Biphenyl-3-yl...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccc2)c1
Show InChI InChI=1S/C24H22N2O4S/c1-3-31(27,28)20-12-13-22(29-2)21(15-20)26-24-25-16-23(30-24)19-11-7-10-18(14-19)17-8-5-4-6-9-17/h4-16H,3H2,1-2H3,(H,25,26)
Affinity DataIC50: 79nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5868(2-Anilino-5-aryloxazole 31 | 5-(4-Fluorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C18H17FN2O4S/c1-3-26(22,23)14-8-9-16(24-2)15(10-14)21-18-20-11-17(25-18)12-4-6-13(19)7-5-12/h4-11H,3H2,1-2H3,(H,20,21)
Affinity DataIC50: 79nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5867(2-Anilino-5-aryloxazole 30 | 5-(4-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)14-8-9-16(24-2)15(10-14)21-18-20-11-17(25-18)12-4-6-13(19)7-5-12/h4-11H,3H2,1-2H3,(H,20,21)
Affinity DataIC50: 81nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5866(2-Anilino-5-aryloxazole 29 | 5-(4-Methoxyphenyl)-N...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(OC)cc2)c1
Show InChI InChI=1S/C19H20N2O5S/c1-4-27(22,23)15-9-10-17(25-3)16(11-15)21-19-20-12-18(26-19)13-5-7-14(24-2)8-6-13/h5-12H,4H2,1-3H3,(H,20,21)
Affinity DataIC50: 87nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5880(2-Anilino-5-aryloxazole 44 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccc2F)c1
Show InChI InChI=1S/C24H21FN2O4S/c1-3-32(28,29)18-11-12-22(30-2)21(14-18)27-24-26-15-23(31-24)17-8-6-7-16(13-17)19-9-4-5-10-20(19)25/h4-15H,3H2,1-2H3,(H,26,27)
Affinity DataIC50: 89nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5872(1-[3-(2-{[5-(Ethylsulfonyl)-2-methoxyphenyl]amino}...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)C(C)=O)c1
Show InChI InChI=1S/C20H20N2O5S/c1-4-28(24,25)16-8-9-18(26-3)17(11-16)22-20-21-12-19(27-20)15-7-5-6-14(10-15)13(2)23/h5-12H,4H2,1-3H3,(H,21,22)
Affinity DataIC50: 91nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5865(2-Anilino-5-aryloxazole 28 | 5-(3-Fluorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(F)c2)c1
Show InChI InChI=1S/C18H17FN2O4S/c1-3-26(22,23)14-7-8-16(24-2)15(10-14)21-18-20-11-17(25-18)12-5-4-6-13(19)9-12/h4-11H,3H2,1-2H3,(H,20,21)
Affinity DataIC50: 93nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5858(2-Anilino-5-aryloxazole 19 | 5-phenyl-N-(3,4,5-tri...)
Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C18H18N2O4/c1-21-14-9-13(10-15(22-2)17(14)23-3)20-18-19-11-16(24-18)12-7-5-4-6-8-12/h4-11H,1-3H3,(H,19,20)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5856(2-Anilino-5-aryloxazole 17 | N-(3,4-Dimethoxypheny...)
Show SMILES COc1ccc(Nc2ncc(o2)-c2ccccc2)cc1OC
Show InChI InChI=1S/C17H16N2O3/c1-20-14-9-8-13(10-15(14)21-2)19-17-18-11-16(22-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,18,19)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5863(2-Anilino-5-aryloxazole 26 | 3-(2-{[5-(ethanesulfo...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C19H17N3O4S/c1-3-27(23,24)15-7-8-17(25-2)16(10-15)22-19-21-12-18(26-19)14-6-4-5-13(9-14)11-20/h4-10,12H,3H2,1-2H3,(H,21,22)
Affinity DataIC50: 141nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5857(2-Anilino-5-aryloxazole 18 | N-(3,5-Dimethoxypheny...)
Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C17H16N2O3/c1-20-14-8-13(9-15(10-14)21-2)19-17-18-11-16(22-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,18,19)
Affinity DataIC50: 170nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5861(2-Anilino-5-aryloxazole 24 | 5-(2-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccccc2Cl)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)12-8-9-16(24-2)15(10-12)21-18-20-11-17(25-18)13-6-4-5-7-14(13)19/h4-11H,3H2,1-2H3,(H,20,21)
Affinity DataIC50: 360nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5848(2-Anilino-5-aryloxazole 9 | N-(2-Methoxyphenyl)-5-...)
Show SMILES COc1ccccc1Nc1ncc(o1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O2/c1-19-14-10-6-5-9-13(14)18-16-17-11-15(20-16)12-7-3-2-4-8-12/h2-11H,1H3,(H,17,18)
Affinity DataIC50: 380nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5851(2-Anilino-5-aryloxazole 12 | N-(3-Hydroxymethylphe...)
Show SMILES OCc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H14N2O2/c19-11-12-5-4-8-14(9-12)18-16-17-10-15(20-16)13-6-2-1-3-7-13/h1-10,19H,11H2,(H,17,18)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5854(2-Anilino-5-aryloxazole 15 | 4-[(5-Phenyl-1,3-oxaz...)
Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccccc2)cc1
Show InChI InChI=1S/C15H13N3O3S/c16-22(19,20)13-8-6-12(7-9-13)18-15-17-10-14(21-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)(H2,16,19,20)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5852(2-Anilino-5-aryloxazole 13 | N-(3-(Ethylsulfonyl)p...)
Show SMILES CCS(=O)(=O)c1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C17H16N2O3S/c1-2-23(20,21)15-10-6-9-14(11-15)19-17-18-12-16(22-17)13-7-4-3-5-8-13/h3-12H,2H2,1H3,(H,18,19)
Affinity DataIC50: 720nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5853(2-Anilino-5-aryloxazole 14 | N-(3-Methylphenyl)-5-...)
Show SMILES Cc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H14N2O/c1-12-6-5-9-14(10-12)18-16-17-11-15(19-16)13-7-3-2-4-8-13/h2-11H,1H3,(H,17,18)
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5847(2-Anilino-5-aryloxazole 8 | 2-[(5-phenyl-1,3-oxazo...)
Show SMILES N#Cc1ccccc1Nc1ncc(o1)-c1ccccc1
Show InChI InChI=1S/C16H11N3O/c17-10-13-8-4-5-9-14(13)19-16-18-11-15(20-16)12-6-2-1-3-7-12/h1-9,11H,(H,18,19)
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5849(2-Anilino-5-aryloxazole 10 | 3-[(5-phenyl-1,3-oxaz...)
Show SMILES N#Cc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H11N3O/c17-10-12-5-4-8-14(9-12)19-16-18-11-15(20-16)13-6-2-1-3-7-13/h1-9,11H,(H,18,19)
Affinity DataIC50: 930nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5364(2-Anilino-5-aryloxazole 5 | N,5-diphenyl-1,3-oxazo...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-3-7-12(8-4-1)14-11-16-15(18-14)17-13-9-5-2-6-10-13/h1-11H,(H,16,17)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5850(2-Anilino-5-aryloxazole 11 | N-(3-Phenoxyphenyl)-5...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C21H16N2O2/c1-3-8-16(9-4-1)20-15-22-21(25-20)23-17-10-7-13-19(14-17)24-18-11-5-2-6-12-18/h1-15H,(H,22,23)
Affinity DataIC50: 1.41E+3nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM5855(2-Anilino-5-aryloxazole 16 | N-(4-Phenoxyphenyl)-5...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H16N2O2/c1-3-7-16(8-4-1)20-15-22-21(25-20)23-17-11-13-19(14-12-17)24-18-9-5-2-6-10-18/h1-15H,(H,22,23)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair