Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 2140
TargetCoagulation factor X(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  40nM ΔG°:  -43.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  57nM ΔG°:  -43.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine protease 1(Bovine)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  67nM ΔG°:  -42.6kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  102nM ΔG°:  -41.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  140nM ΔG°:  -40.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  780nM ΔG°:  -36.3kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  4.10E+3nM ΔG°:  -32.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  6.50E+3nM ΔG°:  -30.8kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPlasminogen(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  6.80E+3nM ΔG°:  -30.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  8.20E+3nM ΔG°:  -30.2kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  9.00E+3nM ΔG°:  -30.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  9.20E+3nM ΔG°:  -29.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  1.30E+4nM ΔG°:  -29.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  1.60E+4nM ΔG°:  -28.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTissue-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCoagulation factor VII(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor VII(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor VII(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi:  4.40E+4nM ΔG°:  -25.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTissue-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >5.00E+4nM ΔG°: >-25.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTissue-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amin...)
Affinity DataKi: >5.00E+4nM ΔG°: >-25.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed