Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 2760
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24341(4-{[(4-chloro-3-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 0.180nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24328(4-{[(4-hydroxy-3-iodophenyl)methyl](4H-1,2,4-triaz...)
Affinity DataIC50: 0.330nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24344(4-({[3-hydroxy-4-(trifluoromethyl)phenyl]methyl}(4...)
Affinity DataIC50: 0.400nMAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10016(4-{[(4-bromophenyl)methyl](4H-1,2,4-triazol-4-yl)a...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24342(4-{[(4-bromo-3-hydroxyphenyl)methyl](4H-1,2,4-tria...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24332(4-{[(3-chloro-4-hydroxy-5-methoxyphenyl)methyl](4H...)
Affinity DataIC50: 0.510nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24340(4-{[(4-fluoro-3-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24335((5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 0.770nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 0.820nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24331(4-({[4-hydroxy-3-(trifluoromethyl)phenyl]methyl}(4...)
Affinity DataIC50: 0.880nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24336((2-chloro-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 0.920nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24327(4-{[(3-bromo-4-hydroxyphenyl)methyl](4H-1,2,4-tria...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24343(4-{[(3-hydroxy-4-methoxyphenyl)methyl](4H-1,2,4-tr...)
Affinity DataIC50: 1.20nMAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24320((4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10019((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24326(4-{[(3-chloro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24329(4-{[(4-hydroxy-3-methoxyphenyl)methyl](4H-1,2,4-tr...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24339(4-{[(3-hydroxyphenyl)methyl](4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24325(4-{[(3-fluoro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 2.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24323((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 2.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24337((2-bromo-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 3.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24333(4-{[(3,5-dichloro-4-hydroxyphenyl)methyl](4H-1,2,4...)
Affinity DataIC50: 7.60nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10018(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24338((5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM10019((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24324(4-{[(4-hydroxyphenyl)methyl](4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 23nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24330(5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]me...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24322((2-cyano-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 27nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10021(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM10018(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24321((4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 42nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM10017(YM511 Analog 4 | (4-{[(4-cyanophenyl)(4H-1,2,4-tri...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24334(4-{[(2,3,5,6-tetrafluoro-4-hydroxyphenyl)methyl](4...)
Affinity DataIC50: 159nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24320((4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM10017(YM511 Analog 4 | (4-{[(4-cyanophenyl)(4H-1,2,4-tri...)
Affinity DataIC50: 227nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24321((4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 380nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24323((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 536nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24335((5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 590nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM10021(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 5.13E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24322((2-cyano-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24336((2-chloro-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24337((2-bromo-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24338((5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed