Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50002028
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 420nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 777nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 559nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 71nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 172nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 104nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 1.30E+3nMAssay Description:Positive allosteric modulation of M5 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 2.15E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 399nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 1.47E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Rat)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 218nMAssay Description:Positive allosteric modulation of rat M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 178nMAssay Description:Positive allosteric modulation of M1 receptor Y179A/W400A mutant (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 516nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 354nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 187nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 3.68E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 267nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 165nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 103nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 180nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 1.85E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 80nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 70nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 311nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 238nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 4.48E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 962nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
