Compile Data Set for Download or QSAR
Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50002028
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452417(CHEMBL4203058)
Affinity DataEC50:  420nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452425(CHEMBL4204548)
Affinity DataEC50:  777nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452424(CHEMBL4205971)
Affinity DataEC50:  559nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452423(CHEMBL4212541)
Affinity DataEC50:  71nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452422(CHEMBL4210464)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452421(CHEMBL4212268)
Affinity DataEC50:  172nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452420(CHEMBL4212168)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452419(CHEMBL4202915)
Affinity DataEC50:  104nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of M5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452416(CHEMBL4214189)
Affinity DataEC50:  2.15E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452415(CHEMBL4204098)
Affinity DataEC50:  399nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452414(CHEMBL4206098)
Affinity DataEC50:  1.47E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  218nMAssay Description:Positive allosteric modulation of rat M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  178nMAssay Description:Positive allosteric modulation of M1 receptor Y179A/W400A mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452448(CHEMBL4218941)
Affinity DataEC50:  317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452447(CHEMBL4218606)
Affinity DataEC50:  516nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452446(CHEMBL4209299)
Affinity DataEC50:  317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452445(CHEMBL4206991)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452444(CHEMBL4207900)
Affinity DataEC50:  354nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452443(CHEMBL4210984)
Affinity DataEC50:  317nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452442(CHEMBL4203218)
Affinity DataEC50:  187nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452441(CHEMBL4211235)
Affinity DataEC50:  3.68E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452413(CHEMBL4213813)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452440(CHEMBL4213275)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452438(CHEMBL4204828)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452437(CHEMBL4206066)
Affinity DataEC50:  267nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452428(CHEMBL4211028)
Affinity DataEC50:  165nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452427(CHEMBL4216615)
Affinity DataEC50:  103nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452426(CHEMBL1492697)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452388(CHEMBL4202501)
Affinity DataEC50:  870nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452395(CHEMBL4217647)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452394(CHEMBL4211802)
Affinity DataEC50:  1.85E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452393(CHEMBL4212760)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50:  70nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452392(CHEMBL4206609)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452391(CHEMBL4215404)
Affinity DataEC50:  311nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452390(CHEMBL4214867)
Affinity DataEC50:  238nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452389(CHEMBL4211633)
Affinity DataEC50:  4.48E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452396(CHEMBL4211355)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452387(CHEMBL4206863)
Affinity DataEC50:  962nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452386(CHEMBL4206346)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452385(CHEMBL4215509)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452384(Sulazepam | W-3676)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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