Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50005436
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492037(CHEMBL2391055)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492043(CHEMBL2391047)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492035(CHEMBL2391054)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057895(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 29nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057898(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 34nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492040(CHEMBL2391049)
Affinity DataIC50: 34nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 61nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492034(CHEMBL2391048)
Affinity DataIC50: 70nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492039(CHEMBL2391052)
Affinity DataIC50: 160nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492038(CHEMBL2391053)
Affinity DataIC50: 190nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492041(CHEMBL2391050)
Affinity DataIC50: 360nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492036(CHEMBL2391056)
Affinity DataIC50: 360nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492042(CHEMBL2391051)
Affinity DataIC50: 440nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057895(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 750nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492035(CHEMBL2391054)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of monocyte COX2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 production after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057898(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 3.23E+3nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057898(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492041(CHEMBL2391050)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492037(CHEMBL2391055)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492042(CHEMBL2391051)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492034(CHEMBL2391048)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50057895(1-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492043(CHEMBL2391047)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492040(CHEMBL2391049)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492039(CHEMBL2391052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492038(CHEMBL2391053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492035(CHEMBL2391054)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492036(CHEMBL2391056)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492034(CHEMBL2391048)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of monocyte COX2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 production after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492039(CHEMBL2391052)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of monocyte COX2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 production after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492035(CHEMBL2391054)
Affinity DataIC50: 5.05E+4nMAssay Description:Inhibition of platelet COX1 in human whole blood assessed as inhibition of serum TXB2 production after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492034(CHEMBL2391048)
Affinity DataIC50: 7.14E+4nMAssay Description:Inhibition of platelet COX1 in human whole blood assessed as inhibition of serum TXB2 production after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492039(CHEMBL2391052)
Affinity DataIC50: 1.61E+5nMAssay Description:Inhibition of platelet COX1 in human whole blood assessed as inhibition of serum TXB2 production after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of monocyte COX2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 production after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 1.25E+7nMAssay Description:Inhibition of platelet COX1 in human whole blood assessed as inhibition of serum TXB2 production after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)