Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50007549
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510359(CHEMBL4466031)
Affinity DataKd:  110nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510351(CHEMBL4571921)
Affinity DataKd:  46nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339166(US10201546, Example 83)
Affinity DataKd:  357nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510354(CHEMBL4441287)
Affinity DataKd:  0.0200nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)
Affinity DataKd:  2.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510355(CHEMBL4552142)
Affinity DataKd:  0.300nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510343(CHEMBL4532727)
Affinity DataKd:  3.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510356(CHEMBL4584135)
Affinity DataKd:  0.600nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510346(CHEMBL4575356)
Affinity DataKd:  1.20nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77C | US9290476, 77B | US9290476, 77A)
Affinity DataKd:  0.100nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339131(US10201546, Example 66a)
Affinity DataEC50:  326nMAssay Description:Agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as increase in RORGgamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510358(CHEMBL4459199)
Affinity DataKd:  4.80nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510344(CHEMBL4555910)
Affinity DataKd:  47nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339216(US10201546, Example 107a | (4-Chloro-3-((4,4-diflu...)
Affinity DataKd:  5.70nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339227(US10201546, Example 191c | US10201546, Example 112...)
Affinity DataKd:  1.10nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510348(CHEMBL4442831)
Affinity DataKd:  0.100nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataKd:  1.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510353(CHEMBL4589288)
Affinity DataEC50:  38nMAssay Description:Agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as increase in RORGgamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339267(US10201546, Example 133a)
Affinity DataKd:  412nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)
Affinity DataKd:  6.10nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339131(US10201546, Example 66a)
Affinity DataKd:  262nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339207(US10201546, Example 103a)
Affinity DataKd:  1.5nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339252(US10201546, Example 126b)
Affinity DataKd:  0.5nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339137(US10201546, Example 69a)
Affinity DataKd:  14nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339134(US10201546, Example 68a)
Affinity DataKd:  3.80nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510350(CHEMBL4438967)
Affinity DataKd:  3.90nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510345(CHEMBL4517932)
Affinity DataKd:  19nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339048(US10201546, Example 12a)
Affinity DataKd:  63nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510347(CHEMBL4475244)
Affinity DataKd:  2.90nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339276(US10201546, Example 136a)
Affinity DataKd:  1.40nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339054(US10201546, Example 14a)
Affinity DataKd:  1.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510353(CHEMBL4589288)
Affinity DataKd:  31nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339144(US10201546, Example 72a)
Affinity DataKd:  8.20nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77C | US9290476, 77B | US9290476, 77A)
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77C | US9290476, 77B | US9290476, 77A)
Affinity DataIC50: 3.90nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510354(CHEMBL4441287)
Affinity DataIC50: 5.10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataIC50: 8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510355(CHEMBL4552142)
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339276(US10201546, Example 136a)
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339252(US10201546, Example 126b)
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339227(US10201546, Example 191c | US10201546, Example 112...)
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339216(US10201546, Example 107a | (4-Chloro-3-((4,4-diflu...)
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339134(US10201546, Example 68a)
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339207(US10201546, Example 103a)
Affinity DataIC50: 22nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510356(CHEMBL4584135)
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)
Affinity DataIC50: 29nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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