Compile Data Set for Download or QSAR
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Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50015871
TargetTyrosine-protein kinase BTK(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) in leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM202554((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of His/TEV-cleavable tagged recombinant JAK3 kinase domain (781 to 1124 residues) (unknown origin) by ELISA analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50528812(CHEMBL4582951)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) in leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | US11896597, Compound EGF816 | WO20...)
Affinity DataIC50:  31nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50590197(CHEMBL5200851)
Affinity DataIC50:  50nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50526795(CHEMBL4450322)
Affinity DataIC50:  54nMAssay Description:Inhibition of CDK7 (unknown origin) in human HAP1 cells incubated for 6 hrs by Western blot based competitive pull down assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50511933(CHEMBL4518287)
Affinity DataIC50:  160nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  240nMAssay Description:Inhibition of CDK7 (unknown origin) in human HAP1 cells incubated for 6 hrs by Western blot based competitive pull down assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50505278(CHEMBL4578515)
Affinity DataIC50:  400nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y181C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM509991(Jun9-62-2R)
Affinity DataIC50:  430nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  440nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus type 1)
College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50505277(CHEMBL4553027)
Affinity DataIC50:  480nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y181C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB