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Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50017396
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  8.80E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181674(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.60E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181671(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.80E+3nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181679(5-(2-methyl-benzothiazol-5-yl)-2-oxo-1,2-dihydro-p...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181682(2-oxo-5-quinoxalin-6-yl-1,2-dihydro-pyridine-3-car...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  6.50E+3nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181682(2-oxo-5-quinoxalin-6-yl-1,2-dihydro-pyridine-3-car...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  7.50E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181673(5-(3,4,5-trimethoxyphenyl)-2-oxo-1,2-dihydro-pyrid...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  9.40E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  9.50E+3nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.12E+4nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.29E+4nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.37E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181683(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181674(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181676(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.46E+4nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181679(5-(2-methyl-benzothiazol-5-yl)-2-oxo-1,2-dihydro-p...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  1.74E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181680(6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic a...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181677(5-benzo[1,3]dioxol-5-yl-2-methoxy-N-[4-(4-methyl-p...)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: >2.50E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181678(5-benzo[1,3]dioxol-5-yl-2-chloro-N-[4-(4-methyl-pi...)
Affinity DataIC50:  2.68E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181678(5-benzo[1,3]dioxol-5-yl-2-chloro-N-[4-(4-methyl-pi...)
Affinity DataIC50:  2.73E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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