Compile Data Set for Download or QSAR
Report error Found 121 Enz. Inhib. hit(s) with all data for entry = 50017982
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataKd:  340nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataKd:  670nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606687(CHEMBL5220246)
Affinity DataKd:  3.90E+3nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50: 63nMAssay Description:Inhibition of human KDM2A preincubated for 15 mins followed by substrate addition and measured after 30 mins using Biotin-H3(28-48)K36Me2 peptide as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM5C (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4E (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4D (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4B (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM2A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 3A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM3A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM6A (unknown origin) expressed in Escherichia coli using Biotin-H3(14-34)K27me3 peptide and measured after 1 hrs by alpha screen assa...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 6B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM6B (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606682(CHEMBL5220094)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 3A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50: 400nMAssay Description:Inhibition of human KDM3A preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(1-21)K9Me2-GGK-Biotin peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606684(CHEMBL5220148)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606685(CHEMBL5219099)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606687(CHEMBL5220246)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606682(CHEMBL5220094)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606683(CHEMBL5220431)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606685(CHEMBL5219099)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606685(CHEMBL5219099)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606684(CHEMBL5220148)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606688(CHEMBL5218469)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606687(CHEMBL5220246)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606678(CHEMBL5219491)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606678(CHEMBL5219491)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606682(CHEMBL5220094)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 3A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606678(CHEMBL5219491)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human KDM3A preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(1-21)K9Me2-GGK-Biotin peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 6B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of human KDM6B preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(21-44)K27Me3-GK-biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606683(CHEMBL5220431)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human FIH preincubated for 15 mins followed by substrate addition and measured after 15 mins using ankyrin peptide HLEVVKLLLEAGADVNAQDK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50328019(2-(3-hydroxypicolinamido)acetic acid | CHEMBL12565...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606678(CHEMBL5219491)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606689(CHEMBL5219135)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of human KDM5B preincubated for 15 mins followed by substrate addition and measured after 20 mins using H3(1-21)K4Me3-GGK-Biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606677(CHEMBL5219094)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of recombinant N-terminal hexahistidine-tagged human PDH2 (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606688(CHEMBL5218469)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of human FIH preincubated for 15 mins followed by substrate addition and measured after 15 mins using ankyrin peptide HLEVVKLLLEAGADVNAQDK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 6B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of human KDM6B preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(21-44)K27Me3-GK-biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
PubMed
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