Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50019368
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  460nMAssay Description:Binding affinity to SIK3 (unknown origin) transfected in HEK293 cells assessed as dissociation constant incubated for 1 hr by competitive binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to SIK2 (unknown origin) transfected in HEK293 cells assessed as dissociation constant incubated for 1 hr by competitive binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to SIK1 (unknown origin) transfected in HEK293 cells assessed as dissociation constant incubated for 1 hr by competitive binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 4nMAssay Description:Inhibition of full-length human ZAK using MBP as substrate in presence off ATP by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618614(CHEMBL5402213)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618614(CHEMBL5402213)
Affinity DataIC50: 6nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 18nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618606(CHEMBL5401391)
Affinity DataIC50: 20nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618606(CHEMBL5401391)
Affinity DataIC50: 25nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618614(CHEMBL5402213)
Affinity DataIC50: 31nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 33nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 48nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 72nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618606(CHEMBL5401391)
Affinity DataIC50: 74nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 89nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618610(CHEMBL5416418)
Affinity DataIC50: 113nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 145nMAssay Description:Inhibition of full length NanoLuc fused EPHA1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618612(CHEMBL5423817)
Affinity DataIC50: 228nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618608(CHEMBL5415867)
Affinity DataIC50: 239nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618610(CHEMBL5416418)
Affinity DataIC50: 277nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618612(CHEMBL5423817)
Affinity DataIC50: 290nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618608(CHEMBL5415867)
Affinity DataIC50: 352nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618613(CHEMBL5409353)
Affinity DataIC50: 429nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-B receptor 4(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 607nMAssay Description:Inhibition of full length NanoLuc fused EPHB4 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-B receptor 1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 632nMAssay Description:Inhibition of full length NanoLuc fused EPHB1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618610(CHEMBL5416418)
Affinity DataIC50: 665nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618611(CHEMBL5417915)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618609(CHEMBL5438800)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618612(CHEMBL5423817)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618613(CHEMBL5409353)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618608(CHEMBL5415867)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-A receptor 4(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full length NanoLuc fused EPHA4 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-A receptor 3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length NanoLuc fused EPHA3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length NanoLuc fused EPHA2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618609(CHEMBL5438800)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618611(CHEMBL5417915)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618613(CHEMBL5409353)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618609(CHEMBL5438800)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618611(CHEMBL5417915)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of full length NanoLuc fused SIK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of full length NanoLuc fused EPHB3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of full length NanoLuc fused EPHB2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibition of full length NanoLuc fused JNK1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of full length NanoLuc fused ABL1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 3.38E+4nMAssay Description:Inhibition of full length NanoLuc fused GAK (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of full length NanoLuc fused RSK1b (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed