Report error Found 132 Enz. Inhib. hit(s) with all data for entry = 50019406
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 150nMAssay Description:Inhibition of human HPK1 in human T cells assessed as increase in IL-2 secretionMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 170nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 3.99E+5nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 6.30E+4nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 140nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 47nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 165nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 310nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 160nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 370nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 850nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 1.90E+3nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 70nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 1.5nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 41nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 175nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 45nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 280nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 235nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 85nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 295nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 450nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 258nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataEC50: 90nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.0970nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation at Ser376 residue preincubated for 60 mins followed by ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length human GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells using MBP and ATP as substrate preincubated for 1...More data for this Ligand-Target Pair
