Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50021429
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CCR2 expressed in THP1 cells assessed as MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224501((E)-2-(4-(7-methoxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224523((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224500((E)-2-(4-(5-amino-1H-indol-3-yl)piperidin-1-yl)-2-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224502((E)-2-(4-(2-methyl-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224511((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224524((E)-2-(4-(5-(methylsulfonamido)-1H-indol-3-yl)pipe...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224519((E)-2-(4-(6-chloro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224512(2-(1-((4-(trifluoromethoxy)phenyl)carbamoyl)piperi...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224508((E)-2-(4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224510((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224521((E)-2-(4-(5-methoxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50: 16.7nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224506((E)-2-(4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224499((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224516(2-(1-((3,4-dichlorophenyl)carbamoyl)piperidin-4-yl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224498((E)-2-(4-(5-fluoro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224515((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-cinna...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224505((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-p-...)
Affinity DataIC50: 115nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224517(2-(1-((4-(trifluoromethyl)phenyl)carbamoyl)piperid...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224507((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224514((R,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224503(2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4-d...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224520(1-(4-((4-(1H-indol-3-yl)piperidin-1-yl)methyl)pipe...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224513((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50: 660nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224495(2-(1-((3,5-dichlorophenyl)carbamoyl)piperidin-4-yl...)
Affinity DataIC50: 720nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224522(2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(phenylca...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224504(2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]-rat MCP1 from rat CCR2 receptor in monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]-mouse MCP1 from CCR2 in mouse WEHI265.1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]-mouse MCP1 from CCR2 in mouse peripheral blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224509(methyl 2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224518((E)-2-(4-(1-acetyl-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50224497(2-(1-((2,3-dichlorophenyl)carbamoyl)piperidin-4-yl...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed