Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50026465
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240963((S)-3,4-dichloro-N-(1-(4-(3-(dimethylamino)propoxy...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A43(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252353(N-((S)-1-((S)-1-(3-bromo-4-(piperidin-4-yloxy)benz...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  4nMAssay Description:Displacement of [I125]hU2 from human recombinant urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252147(N-((S)-1-((R)-3-bromo-4-((R)-pyrrolidin-3-yloxy)be...)
Affinity DataKi:  5.5nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252197((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)phenethyl)p...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252355(N-((S)-1-((S)-1-(3-bromo-4-(piperidin-4-yloxy)phen...)
Affinity DataKi:  12nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252198((S)-N-(1-(3-chloro-4-(piperidin-4-yloxy)phenethyl)...)
Affinity DataKi:  15nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252354(N-((S)-1-((S)-1-((R)-3-bromo-4-((R)-pyrrolidin-3-y...)
Affinity DataKi:  18nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252239((S)-N-(1-(3-methoxy-4-(piperidin-4-yloxy)phenethyl...)
Affinity DataKi:  36nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  38nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252096((+/-)-N-(1-(3-bromo-4-(1-methylpyrrolidin-3-yloxy)...)
Affinity DataKi:  41nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252241((S)-N-(1-(4-(piperidin-4-yloxy)phenethyl)pyrrolidi...)
Affinity DataKi:  42nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252148(N-((S)-1-((S)-3-bromo-4-((S)-pyrrolidin-3-yloxy)be...)
Affinity DataKi:  44nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252095((+/-)-N-(1-(3-chloro-4-(1-methylpyrrolidin-3-yloxy...)
Affinity DataKi:  47nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252097((S)-N-(1-(3-bromo-4-(3-(dimethylamino)propoxy)benz...)
Affinity DataKi:  61nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252199((S)-N-(1-(3-fluoro-4-(piperidin-4-yloxy)phenethyl)...)
Affinity DataKi:  62nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252240((S)-N-(1-(3-nitro-4-(piperidin-4-yloxy)phenethyl)p...)
Affinity DataKi:  69nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252311((+/-)-N-(1-(3-bromo-4-(piperidin-4-yloxy)phenylsul...)
Affinity DataKi:  71nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  85nMAssay Description:Binding affinity at 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252041((+/-)-N-(1-(4-(1-methylpyrrolidin-3-yloxy)benzyl)p...)
Affinity DataKi:  97nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  100nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252042((+/-)-N-(1-(3-methyl-4-(1-methylpyrrolidin-3-yloxy...)
Affinity DataKi:  108nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240962(Benzo[b]thiophene-2-carboxylic acid ((S)-1-{(R)-1-...)
Affinity DataKi:  110nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252242((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)phenylsulfo...)
Affinity DataKi:  120nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  140nMAssay Description:Binding affinity to 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252312(N-(1-(3-bromo-4-(piperidin-4-yloxy)phenylsulfonyl)...)
Affinity DataKi:  140nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  140nMAssay Description:Binding affinity at 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240963((S)-3,4-dichloro-N-(1-(4-(3-(dimethylamino)propoxy...)
Affinity DataKi:  200nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252196((S)-N-(1-(4-(1-benzylpiperidin-4-yloxy)-3-bromoben...)
Affinity DataKi:  230nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240961((S)-N-(1-(4-(3-(dimethylamino)propoxy)benzyl)pyrro...)
Affinity DataKi:  320nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50251944((R)-N-(1-(4-(3-(dimethylamino)propoxy)benzyl)pyrro...)
Affinity DataKi:  350nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252310((R)-N-(1-(3-bromo-4-(piperidin-4-yloxy)phenylsulfo...)
Affinity DataKi:  380nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50251890(N-(1-(4-(3-(dimethylamino)propoxy)benzyl)piperidin...)
Affinity DataKi:  500nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252098((S)-N-(1-(3-bromo-4-(2-(pyrrolidin-1-yl)ethoxy)ben...)
Affinity DataKi:  1.00E+3nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252146((S)-N-(1-(3-bromo-4-(2-(piperazin-1-yl)ethoxy)benz...)
Affinity DataKi:  1.50E+3nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252039((S)-N-(1-(3-(3-(dimethylamino)propoxy)benzyl)pyrro...)
Affinity DataKi: >3.00E+3nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252145((S)-N-(1-(3-bromo-4-(2-morpholinoethoxy)benzyl)pyr...)
Affinity DataKi:  3.50E+3nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  4.10E+3nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi:  7.20E+3nMAssay Description:Binding affinity to 5HT1F receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50251891((4-(4-(3-(dimethylamino)propoxy)benzyl)piperazin-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50251892(N-(3-((4-(3-(dimethylamino)propoxy)benzyl)(methyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252040((S)-N-(1-(2-(3-(dimethylamino)propoxy)benzyl)pyrro...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human recombinant urotensin 2 receptor expressed in HEK293 cells assessed as inhibition of urotensin 2-induced calcium mobiliz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to beta 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed