Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50027491
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50: 130nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(N-[(1S)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 150nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 170nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 175nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275675(N-(2-chlorobenzyl)-5-(2,2,2-trifluoroacetyl)thioph...)
Affinity DataIC50: 190nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50: 230nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50: 310nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 360nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275676(2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-...)
Affinity DataIC50: 410nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275675(N-(2-chlorobenzyl)-5-(2,2,2-trifluoroacetyl)thioph...)
Affinity DataIC50: 550nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50: 560nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25184(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)-1H-pyrrol...)
Affinity DataIC50: 580nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 650nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 670nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 830nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 840nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50: 890nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275676(2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275677(N-(cyclohexylmethyl)-5-(2,2,2-trifluoroacetyl)pico...)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(N-[(1S)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(N-[(1S)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-trifluoroacetyl...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed