Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50027717
TargetSerine/threonine-protein kinase Nek7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human NEK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  6nMAssay Description:Binding affinity to human FRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  7nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  80nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human LIMK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  42nMAssay Description:Binding affinity to human PDGFRBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  111nMAssay Description:Binding affinity to human KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  367nMAssay Description:Binding affinity to human GAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263295(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-[(3-ter...)
Affinity DataKd:  46nMAssay Description:Binding affinity to human EPHA3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MARK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to human MARK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  1.23E+3nMAssay Description:Binding affinity to human MNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  58nMAssay Description:Binding affinity to human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataKd:  1.87E+3nMAssay Description:Binding affinity to human ARGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataKd:  16nMAssay Description:Binding affinity to human PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MARK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataKd:  207nMAssay Description:Binding affinity to human MARK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human MPSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  149nMAssay Description:Binding affinity to human FESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to human PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  92nMAssay Description:Binding affinity to human BRSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human AMPKA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  94nMAssay Description:Binding affinity to human MSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  31nMAssay Description:Binding affinity to human MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataKd:  361nMAssay Description:Binding affinity to human SRPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataKd:  353nMAssay Description:Binding affinity to human DRAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273542(4'-Amino-4''-sulfamoyl-[1,1';3',1'']terphenyl-4,5'...)
Affinity DataKd:  79nMAssay Description:Binding affinity to human p38-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  225nMAssay Description:Binding affinity to human CK1alpha2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  596nMAssay Description:Binding affinity to human AXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  483nMAssay Description:Binding affinity to human NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  160nMAssay Description:Binding affinity to human TNIKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase STK11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  380nMAssay Description:Binding affinity to human LKB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  35nMAssay Description:Binding affinity to human PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241256(N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263295(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-[(3-ter...)
Affinity DataKd:  122nMAssay Description:Binding affinity to human FRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  59nMAssay Description:Binding affinity to human CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  85nMAssay Description:Binding affinity to human TNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor-related protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  276nMAssay Description:Binding affinity to human IRRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  53nMAssay Description:Binding affinity to human KHS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  33nMAssay Description:Binding affinity to human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  77nMAssay Description:Binding affinity to human ROSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  52nMAssay Description:Binding affinity to human LTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataKd:  623nMAssay Description:Binding affinity to human SLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  96nMAssay Description:Binding affinity to human DRAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataKd:  150nMAssay Description:Binding affinity to human SKMLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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