Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50028625
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to p38alpha by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277615(1-(5-tert-butyl-2-methoxyphenyl)-3-(4-(6-(morpholi...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to p38alpha by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JNK2alpha2 by by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
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PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218689(N-[5-tert-butyl-2-methoxy-3-(3-naphthalen-1-yl-ure...)
Affinity DataIC50: 79nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 480nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 880nMAssay Description:Inhibition of crafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218677(benzo[b]thiophene-2-carboxylic acid (5-tert-Butyl-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HEKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277627(1-(5-tert-butyl-2-methoxyphenyl)-3-(naphthalen-1-y...)
Affinity DataIC50: 3.90E+3nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218695(benzofuran-2-carboxylic acid (5-tert-Butyl-3-metha...)
Affinity DataIC50: 4.10E+3nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of ECKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of PKBalpha/Akt1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of bRafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277662(N-(5-tert-butyl-2-methoxyphenyl)benzofuran-2-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277663(N-(5-tert-butyl-2-methoxyphenyl)benzo[b]thiophene-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to p38alpha assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed