Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50039347
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335203(N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N2-[(1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335212(N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-5-methyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335210(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335205(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335209(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335211(5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335209(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335215((S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335206(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335208(N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-me...)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335214(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335207(N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-5-fluoro-N2...)
Affinity DataIC50: 16nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335213((S)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 5A(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335208(N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-me...)
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335216(N2-[(1S)-1-(5-Fluoropyrimidin-2-yl)ethyl]-N4-(5-me...)
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 5A(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 58nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335210(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 108nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335205(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)
Affinity DataIC50: 108nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335208(N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-me...)
Affinity DataIC50: 200nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335204((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)
Affinity DataIC50: 346nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335206(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)
Affinity DataIC50: 488nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335207(N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-5-fluoro-N2...)
Affinity DataIC50: 815nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335204((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335210(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335214(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)
Affinity DataIC50: 4.59E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335211(5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335212(N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-5-methyl...)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335215((S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335213((S)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335204((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335205(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335206(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335207(N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-5-fluoro-N2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335217(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335209(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.05E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed