Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50039358
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of His-tagged human FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins before ole...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.40nMAssay Description:Irreversible inhibition of His-tagged rat FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335380(N-Pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP3A4 uisng testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335380(N-Pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335379(N-(6-Methylpyridin-3-yl)-4-(3-{[5-(trifluoromethyl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335379(N-(6-Methylpyridin-3-yl)-4-(3-{[5-(trifluoromethyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 uisng testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335380(N-Pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP3A4 uisng midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335379(N-(6-Methylpyridin-3-yl)-4-(3-{[5-(trifluoromethyl...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of CYP3A4 uisng midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335378(N-Pyrazin-2-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of CYP3A4 uisng testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335378(N-Pyrazin-2-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 uisng testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 uisng midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335378(N-Pyrazin-2-yl-4-(3-{[5-(trifluoromethyl)pyridin-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 uisng midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed