Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with all data for entry = 50039364
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataEC50:  9.10nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570({1-[4-(2-{Hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-...)
Affinity DataEC50:  3.50E+3nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335576((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataEC50:  53nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataEC50:  144nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  366nMAssay Description:Agonist activity at human KOP receptor expressed in HEK-293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  1.77E+3nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335567((1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human KOP receptor expressed in HEK-293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335569(1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-...)
Affinity DataEC50:  194nMAssay Description:Agonist activity at human KOP receptor expressed in HEK-293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335573((1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimida...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335575((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataEC50:  1.22E+3nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335570({1-[4-(2-{Hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-...)
Affinity DataEC50:  12nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335575((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataEC50:  8.90nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataIC50: 0.00490nMAssay Description:Inhibition of human monoamine oxidase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15579(US8633208, Deprenyl | CHEMBL972 | L-Deprenyl | SLG...)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of human monoamine oxidase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of rat SK Calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50022775(m-Trimethylammoniumphenyldimethylcarbamate | Prost...)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009338(Sar-Arg-Val-Tyr-Val-His-Pro-Ala | (S)-2-((S)-1-((S...)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human angiotensin II AT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009338(Sar-Arg-Val-Tyr-Val-His-Pro-Ala | (S)-2-((S)-1-((S...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human angiotensin II AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine 3-monooxygenase(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM37633(cid_439744 | MLS000069664 | (2S)-2-amino-3-(4-hydr...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of rat tyrosine hydroxylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of guinea pig histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335566(CHEMBL1651026 | Substance P [Sar9,Met(O2)11])
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human tachykinin NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25768(ICI 118,551 | 1-[(7-methyl-2,3-dihydro-1H-inden-4-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human alpha2 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human 5-HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50292408(5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human leukotriene D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22165(Vanoxerine | CHEMBL542933 | GBR-12909 | CHEMBL5438...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human 5-HT transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataIC50: 10nMAssay Description:Inhibition of human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataIC50: 12nMAssay Description:Inhibition of human dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21281(WIN55212-2 | CHEMBL188 | (2,3-dihydro-5-methyl-3-(...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human cannabinoid CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human aorepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM39341(PIRENZEPINE DIHYDROCHLORIDE | SMR000058502 | MLS00...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064176(METHOCTRAMINE | N,N''-Bis-[6-(2-methoxy-benzylamin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 67nMAssay Description:Inhibition of human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22889(N-methyl-N-[2-(5-methyl-1H-4-imidazolylmethylsulfa...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of guinea pig histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25753(Artrenolol | 2-{4-[2-hydroxy-3-(propan-2-ylamino)p...)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human alpha1 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335574((1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]pip...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335575((1-{4-[2-(3-Chloro-4-fluorophenyl)-1H-benzimidazol...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
Displayed 1 to 50 (of 90 total ) | Next | Last >>
Jump to: