Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50049323
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM246524(Psoralidin (5))
Affinity DataKd:  2.10E+4nMAssay Description:Binding affinity to recombinant human 6His-tagged FLAP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  9.00E+3nMAssay Description:Agonist activity at FXR (unknown origin) assessed as recruitment of SRC1 peptide to FXR by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at FXR (unknown origin) assessed as recruitment of SRC1 peptide to FXR by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataEC50:  3.06E+4nMAssay Description:Activation of human PXR expressed in DPX2 cells assessed as CYP3A4 induction after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataIC50: 0.0440nMAssay Description:Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50239015(CHEBI:6993 | MK-476 | Montelukast Sodium | Singula...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50239014(CHEMBL4102154)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50227141(CHEMBL174483)
Affinity DataIC50: 240nMAssay Description:Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50227367(CHEMBL48435)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50015529(CHEMBL298727 | 4-(5-Cyclopentyloxycarbonylamino-1-...)
Affinity DataKi:  157nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed