Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for assayid = 1 entry = 6319
TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123054(US8742134, (1))
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/mole IC50: 0.230nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
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TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123055(US8742134, (7) | US8742134, (2))
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/mole IC50: 0.25nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123056(US8742134, (8) | US8742134, (3))
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/mole IC50: 0.25nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123057(US8742134, (5) | US8742134, (6) | US8742134, (4))
Affinity DataKi:  0.220nM ΔG°:  -54.6kJ/mole IC50: 0.300nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123057(US8742134, (5) | US8742134, (6) | US8742134, (4))
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole IC50: 2.10nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123057(US8742134, (5) | US8742134, (6) | US8742134, (4))
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/mole IC50: 2.90nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123055(US8742134, (7) | US8742134, (2))
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole IC50: 19nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theron Pharmaceuticals

US Patent
LigandPNGBDBM123056(US8742134, (8) | US8742134, (3))
Affinity DataKi:  26nM ΔG°:  -42.9kJ/mole IC50: 36nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent