Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50004326
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481800(CHEMBL1086908)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3C[C@H](O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H40O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-22,28,30H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,22-,24-,25+,26+/m0/s1
Affinity DataIC50: 800nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481801(CHEMBL1086909)
Show SMILES COC(=O)[C@]12CCCC(C)(C)[C@@H]1CC[C@@]1(C)[C@@H]3CC=C([C@H](C=O)[C@@]3(C)C(=O)C[C@H]21)C(C)=O
Show InChI InChI=1S/C27H38O5/c1-16(29)17-8-9-20-25(4)13-10-19-24(2,3)11-7-12-27(19,23(31)32-6)21(25)14-22(30)26(20,5)18(17)15-28/h8,15,18-21H,7,9-14H2,1-6H3/t18-,19-,20-,21-,25-,26+,27+/m0/s1
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481802(CHEBI:67727 | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid