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Found 18 Enz. Inhib. hit(s) with all data for assayid = 3 entry = 9759
TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50:  1.92E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  3.93E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50:  6.39E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  8.25E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50:  8.84E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50:  1.19E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  1.21E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  2.04E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50:  2.15E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50:  2.22E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486449((4R,5R)-4-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2...)
Affinity DataIC50:  2.33E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: >4.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486452((R,Z)-6-(2-(6-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: >4.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  4.15E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  5.24E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486446((4R,5R)-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  6.64E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486448(5-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  9.71E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  1.19E+6nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
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