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Found 22 of ph data with Target = 'Histamine H1 receptor'
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM255474(US9481688, 1 | US9481688, 3)
Affinity DataKi:  20.6nM ΔG°:  -43.9kJ/molepH: 7.6 T: 2°CAssay Description:[3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared ...More data for this Ligand-Target Pair
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TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM255474(US9481688, 1 | US9481688, 3)
Affinity DataKi:  58.8nM ΔG°:  -41.3kJ/molepH: 7.6 T: 2°CAssay Description:[3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared ...More data for this Ligand-Target Pair
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TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  977nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM26226((12S,17S)-6-(piperazin-1-yl)-11-oxa-3,5-diazatetra...)
Affinity DataKi:  3.55E+3nM ΔG°:  -31.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM27213(4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imi...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293397(US10106522, Example 1)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293403(US10106522, Example 3)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293407(US10106522, Example 5)
Affinity DataIC50:  54nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293406(US10106522, Example 4)
Affinity DataIC50:  93nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293400(US10106522, Example 2)
Affinity DataIC50:  115nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293409(US10106522, Example 8)
Affinity DataIC50:  169nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293408(US10106522, Example 7)
Affinity DataIC50:  175nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293410(US10106522, Example 9)
Affinity DataIC50:  195nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293414(US10106522, Compound I-11 in CN 103896915)
Affinity DataIC50:  260nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293413(US10106522, Compound I-3 in CN 103896915)
Affinity DataIC50:  271nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293411(US10106522, Example 5 in EP 0580541)
Affinity DataIC50:  424nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM293412(US10106522, Compound I-8 in CN 103896915)
Affinity DataIC50:  1.99E+3nMpH: 7.4 T: 2°CAssay Description:Affinity for histamine H1-receptor was determined by binding studies to H1 receptors. The sample used is a suspension of membranes of CHO cells trans...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent