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Found 79 of ph data with Target = 'Receptor tyrosine-protein kinase erbB-2'
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228119((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228121((e)-n-(7-ethoxy-4-((1-(3-fluorobenzyl)-1h-indazol-...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228117((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228116((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228115((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228120((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  2.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228118((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228114((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228122((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  3.70nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228123((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  6.60nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228125((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-et...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228109((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxy...)
Affinity DataIC50:  8.10nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228124((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-me...)
Affinity DataIC50:  9.10nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228126((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-(2...)
Affinity DataIC50:  9.60nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27974(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5459(6-alkoxy-4-anilinoquinazoline 8e | N-{3-chloro-4-[...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228111((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(2-met...)
Affinity DataIC50:  10.4nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM92454(SYR127063)
Affinity DataIC50:  11nMpH: 7.5Assay Description:The EGFR, HER2 and HER4 kinase assay were performed using radiolabeled [gamma-32P] ATP from GE Healthcare. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228110((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(((s)-...)
Affinity DataIC50:  11.7nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27971(6-Ethynylthieno[3,2-d]pyrimidine, 6 | N-{3-chloro-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  13nMpH: 7.5Assay Description:The EGFR, HER2 and HER4 kinase assay were performed using radiolabeled [gamma-32P] ATP from GE Healthcare. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27973(6-Ethynylthieno[3,2-d]pyrimidine, 8 | N-{3-chloro-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27970(1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5443(6-Thiazolylquinazoline 5 | N-[4-(benzyloxy)-3-chlo...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228107( (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-metho...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5444(6-Thiazolylquinazoline 6 | CHEMBL453376 | N-{3-chl...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228113((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(metho...)
Affinity DataIC50:  15.8nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  16.7nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27968(4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,...)
Affinity DataIC50:  17nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM92453(TAK-285)
Affinity DataIC50:  17nMpH: 7.5Assay Description:The EGFR, HER2 and HER4 kinase assay were performed using radiolabeled [gamma-32P] ATP from GE Healthcare. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228128((e)-n-(4-((3-chloro-2,4-difluorophenyl)amino)-7-me...)
Affinity DataIC50:  17.8nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27975(6-Ethynylthieno[2,3-d]pyrimidine, 10 | N-{3-chloro...)
Affinity DataIC50:  19nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5460(6-alkoxy-4-anilinoquinazoline 8f | N-{1-[(3-fluoro...)
Affinity DataIC50:  19nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228127((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-((...)
Affinity DataIC50:  20.3nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27972(6-Ethynylthieno[3,2-d]pyrimidine, 7 | 6-[(3S)-3-am...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5441(6-Thiazolylquinazoline 3 | N-(1-benzyl-1H-indazol-...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228108((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-methox...)
Affinity DataIC50:  31nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27976(6-Ethynylthieno[2,3-d]pyrimidine, 11 | 6-[(3S)-3-a...)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27965(3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228112((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,2,2...)
Affinity DataIC50:  44nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5440(6-Thiazolylquinazoline 2 | N-[4-(benzyloxy)phenyl]...)
Affinity DataIC50:  48nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27978(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50:  52nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27964(3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...)
Affinity DataIC50:  53nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27969(3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27977(6-Ethynylthieno[2,3-d]pyrimidine, 12 | N-{3-chloro...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM27966(1-{4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H...)
Affinity DataIC50:  59nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50169697(CHEMBL182254 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...)
Affinity DataIC50: >63nMpH: 7.5Assay Description:Inhibitory concentration against ErbB-2 protein tyrosine kinase by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM112501(US8623883, No. 7)
Affinity DataIC50:  84.0nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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