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Found 70 of ph data with Target = 'Tyrosine-protein phosphatase non-receptor type 11'
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM199180(US9217012, 10)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 7.0 T: 2°CAssay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24516((2E,5E)-5-[(4-methoxyphenyl)methylidene]-2-(1,3-th...)
Affinity DataKi:  1.17E+4nM ΔG°:  -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24524((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-metho...)
Affinity DataKi:  1.17E+4nM ΔG°:  -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24523((2E,5E)-2-{[4-(adamantan-1-yl)-1,3-thiazol-2-yl]im...)
Affinity DataKi:  1.23E+4nM ΔG°:  -28.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24526((2E,5E)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylid...)
Affinity DataKi:  1.29E+4nM ΔG°:  -27.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24527((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-nitro...)
Affinity DataKi:  1.62E+4nM ΔG°:  -27.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24525((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-hydro...)
Affinity DataKi:  1.81E+4nM ΔG°:  -27.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24529((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...)
Affinity DataKi:  2.28E+4nM ΔG°:  -26.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24515((2E,5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]...)
Affinity DataKi:  2.56E+4nM ΔG°:  -26.2kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24528((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(3-nitro...)
Affinity DataKi:  2.87E+4nM ΔG°:  -25.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24521((2E,5E)-5-[(2-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  3.23E+4nM ΔG°:  -25.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24519((2E,5E)-5-[(4-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  5.45E+4nM ΔG°:  -24.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24530((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-hydro...)
Affinity DataKi:  9.08E+4nM ΔG°:  -23.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24522((2E,5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]...)
Affinity DataKi:  1.03E+5nM ΔG°:  -22.8kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24513((2E,5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-th...)
Affinity DataKi:  3.88E+5nM ΔG°:  -19.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24517((2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataKi:  4.74E+5nM ΔG°:  -19.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24518((2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataKi:  5.48E+5nM ΔG°:  -18.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM24520((2E,5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  1.09E+6nM ΔG°:  -16.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38042(US10093646, Example 12 | US10774065, Example 12 | ...)
Affinity DataIC50:  65nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38045(US10093646, Example 13 | US10774065, Example 13 | ...)
Affinity DataIC50:  65nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38048(US10093646, Example 14 | US10774065, Example 14 | ...)
Affinity DataIC50:  68nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  70nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38067(US10093646, Example 15 | US10774065, Example 15 | ...)
Affinity DataIC50:  75nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  76nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38073(US10093646, Example 18 | US10774065, Example 18 | ...)
Affinity DataIC50:  93nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38069(US10093646, Example 16)
Affinity DataIC50:  93nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38072(US10093646, Example 17 | US10774065, Example 17 | ...)
Affinity DataIC50:  102nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38151(US10093646, Example 21 | US10774065, Example 21 | ...)
Affinity DataIC50:  102nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38102(US10093646, Example 19 | US10774065, Example 19 | ...)
Affinity DataIC50:  110nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38029(US10093646, Example 9 | US10774065, Example 9 | US...)
Affinity DataIC50:  358nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38105(US10093646, Example 20 | US10774065, Example 20 | ...)
Affinity DataIC50:  404nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38155(US10093646, Example 28 | US10774065, Example 28 | ...)
Affinity DataIC50:  632nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38022(US10093646, Example 2 | US10774065, Example 2 | US...)
Affinity DataIC50:  858nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38040(US10093646, Example 10 | US10774065, Example 10 | ...)
Affinity DataIC50:  908nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38024(US10093646, Example 3 | US10774065, Example 3 | US...)
Affinity DataIC50:  950nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38025(US10093646, Example 4 | US10774065, Example 4 | US...)
Affinity DataIC50:  974nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38041(US10093646, Example 11)
Affinity DataIC50:  1.00E+3nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM231697(RR601)
Affinity DataIC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:Assays with and without inhibitor were performed in Corning 96-well clear bottom plates having a nonbinding surface, with a total assay volume of 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50:  2.30E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38165(US10093646, Example 29 | US10774065, Example 29 | ...)
Affinity DataIC50:  2.59E+3nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM124264(Bis(4-nitro-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50:  2.60E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38026(US10093646, Example 5 | US10774065, Example 5 | US...)
Affinity DataIC50:  2.86E+3nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50:  4.20E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50087856(CHEMBL3426913)
Affinity DataIC50:  5.40E+3nMpH: 7.0Assay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50308158(3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...)
Affinity DataIC50:  5.50E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50:  5.70E+3nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50308159(6-hydroxy-1-methyl-3-(1-(2-(4-morpholinophenylamin...)
Affinity DataIC50:  7.80E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50308162(6-hydroxy-1-methyl-3-(1-(5-oxo-5-(10H-phenothiazin...)
Affinity DataIC50:  8.00E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50308161(3-(1-(2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)-1H...)
Affinity DataIC50:  9.10E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University Research And Technology

US Patent
LigandPNGBDBM50308164(3-(1-(2-(biphenyl-4-ylamino)-2-oxoethyl)-1H-1,2,3-...)
Affinity DataIC50:  9.30E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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