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Found 6 of affinity data with PDB=2QK5
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human BACE by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  20nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACEMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  31nMAssay Description:Binding affinity to BACE assessed as displacement of [3H]BMS-599240More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 in human HEK293 cells overexpressing APP with Swedish mutation assessed as inhibition of amyloidbeta 40 productionMore data for this Ligand-Target Pair