Compile Data Set for Download or QSAR
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Found 5 of affinity data with PDB=5FBE
TargetComplement factor D [24-253](Homo sapiens (Human))
Novartis Pharma

LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50:  1.37E+4nMpH: 7.5 T: 2°CAssay Description:Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetComplement factor D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50:  1.40E+4nMAssay Description:Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetComplement factor D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant complement factor D catalytic domain (unknown origin) using Z-Lys-thiobenzyl as substrate pretreated for 1 hr followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetComplement factor D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetComplement factor D [24-253](Homo sapiens (Human))
Novartis Pharma

LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50:  3.32E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant human FD (10 nM concentration) was incubated with compound at various concentrations for 1 h at room temperature in 0.1 M PBS (pH 7.4) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB