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Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM561456(US11390625, Compound 44 | US11390625, Example 44)

IC50: 0.210nMAssay Description:TBDMore data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495017(US10994015, Example 313 | US10994015, Example 314)

IC50: 0.260nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM561455(US11390625, Compound 41 | US11390625, Example 41)

IC50: 0.260nMAssay Description:TBDMore data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495012(US10994015, Example 308)

IC50: 0.270nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495016(US10994015, Example 312)

IC50: 0.350nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495019(US10994015, Example 319)

IC50: 0.800nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495009(US10994015, Example 305)

IC50: 1.30nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547941(WO2022090481, Example I-162)

IC50: 7.80nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625598(US20230322822, Compound 14)

IC50: 10.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625596(US20230322822, Compound 11)

IC50: 12.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547965(WO2022090481, Example I-186)

IC50: 13nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)

IC50: 14nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547940(WO2022090481, Example I-161)

IC50: 15nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625600(US20230322822, Compound 32)

IC50: 15.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495010(US10994015, Example 306)

IC50: 16nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494991(US10994015, Example 287)

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495015(US10994015, Example 311)

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625594(US20230322822, Compound 6)

IC50: 16.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625597(US20230322822, Compound 12)

IC50: 16.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495008(US10994015, Example 304)

IC50: 17nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547983(WO2022090481, Example I-204)

IC50: 19nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495017(US10994015, Example 313 | US10994015, Example 314)

IC50: 20nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625592(US20230322822, Compound 2)

IC50: 21.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495014(US10994015, Example 310)

IC50: 22nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625591(US20230322822, Compound 1)

IC50: 22.2nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM547888(WO2022090481, Example I-107)

IC50: 24nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494936(2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...)

IC50: 25nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495013(US10994015, Example 309)

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625593(US20230322822, Compound 5)

IC50: 30nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM495005(2-(2,6-dioxopiperidin-3-yl)-5-(4-(3-(4-(4-(2-((1-i...)

IC50: 34nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494934(2-(2,6-dioxopiperidin-3-yl)-5-(2-(4-(2-((1-isoprop...)

IC50: 36nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625597(US20230322822, Compound 12)

IC50: 37.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625595(US20230322822, Compound 9)

IC50: 39.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625599(US20230322822, Compound 24)

IC50: 54nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625599(US20230322822, Compound 24)

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625610(US20230322822, Compound 30)

IC50: 62.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625592(US20230322822, Compound 2)

IC50: 64.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494979(US10994015, Example 275)

IC50: 69nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625594(US20230322822, Compound 6)

IC50: 74.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625598(US20230322822, Compound 14)

IC50: 76.4nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625596(US20230322822, Compound 11)

IC50: 82.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625600(US20230322822, Compound 32)

IC50: 85.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625611(US20230322822, Compound 33)

IC50: 90.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625613(US20230322822, Compound 36)

IC50: 95.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494929(2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-((1-isopropyl-...)

IC50: 96nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625614(US20230322822, Compound 37)

IC50: 96.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625591(US20230322822, Compound 1)

IC50: 96.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM494965(US10994015, Example 254)

IC50: 100nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair

Epidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM625593(US20230322822, Compound 5)

IC50: 119nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair