Compile Data Set for Download or QSAR
maximum 50k data
Found 113 of ic50 data for polymerid = 2324,2325
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23057(alpha-ketooxazole, 5cc | methyl 4-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole IC50:  0.240nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23079(3-[4-(benzyloxy)phenyl]-1-{pyrido[2,3-d][1,3]oxazo...)
Affinity DataKi:  0.380nM ΔG°:  -53.8kJ/mole IC50:  0.300nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23055(alpha-ketooxazole, 5aa | methyl 2-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole IC50:  0.400nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23056(alpha-ketooxazole, 5bb | methyl 3-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/mole IC50:  0.400nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23051(7-(4-nitrophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  6.5nM ΔG°:  -46.3kJ/mole IC50:  0.5nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23078(3-(4-phenylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  0.75nM ΔG°:  -52.1kJ/mole IC50:  0.700nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23069(3-[4-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-ox...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/mole IC50:  1nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23061(7-(3-chlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/mole IC50:  2nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23073(3-[4-(phenoxymethyl)phenyl]-1-[5-(pyridin-2-yl)-1,...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/mole IC50:  2nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23077(3-[4-(phenylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  2.20nM ΔG°:  -49.4kJ/mole IC50:  2nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23074(3-(4-phenoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  3.40nM ΔG°:  -48.3kJ/mole IC50:  2nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23120(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Affinity DataKi:  4.70nM ΔG°:  -47.5kJ/mole IC50:  2nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23076(3-(4-benzylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3.20nM ΔG°:  -48.5kJ/mole IC50:  3nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23065(7-(3-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/mole IC50:  4nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23042(7-(4-aminophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/mole IC50:  4nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23075(3-[4-(phenylamino)phenyl]-1-[5-(pyridin-2-yl)-1,3-...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/mole IC50:  5nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23063(7-(2,3-dichlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxa...)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/mole IC50:  7nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23054(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[4-(trifluo...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/mole IC50:  9nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23046(7-(3-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23030(7-(naphthalen-1-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  2.60nM ΔG°:  -48.5kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23049(7-[3-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  4.20nM ΔG°:  -47.3kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23038(7-(2-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  5.80nM ΔG°:  -46.5kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23102(2-(4-phenylbutoxy)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  60nM ΔG°:  -41.2kJ/mole IC50:  10nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23053(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[3-(trifluo...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23060(7-(2-chlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  1.90nM ΔG°:  -49.8kJ/mole IC50:  20nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23039(7-(3-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23050(7-[4-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23047(7-(4-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23027(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(thiophen-2...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23040(7-(4-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  6.20nM ΔG°:  -46.4kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23033(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(pyridin-3-...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23045(7-(2-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23062(7-(4-chlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50:  30nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23034(7-(2-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23036(7-(3-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3.30nM ΔG°:  -47.9kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23048(7-[2-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  3.30nM ΔG°:  -47.9kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23052(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[2-(trifluo...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23067(7-(4-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  6.70nM ΔG°:  -46.7kJ/mole IC50:  30nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23032(7-(pyridin-2-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23037(7-(4-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  2.80nM ΔG°:  -48.3kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23029(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(thiophen-3...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23031(7-(naphthalen-2-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23066(7-(4-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,...)
Affinity DataKi:  19nM ΔG°:  -44.1kJ/mole IC50:  50nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23068(7-(3-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/mole IC50:  80nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23071(3-[3-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-ox...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/mole IC50:  100nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM23064(7-(2-methanesulfonylphenyl)-1-[5-(pyridin-2-yl)-1,...)
Affinity DataKi:  37nM ΔG°:  -42.4kJ/mole IC50:  100nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50262041(5-(((5-carboxy-2-methylfuran-3-yl)methylthio)methy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50431467(CHEMBL2348305)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human DNA ligase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Bacteriophage T4)
India Central Drug Research Institute

LigandPNGBDBM22984((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Affinity DataIC50:  3.00E+3nMpH: 7.6 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50262039(3-amino-2-(benzylideneamino)-5-mercaptophenol | CH...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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