Compile Data Set for Download or QSAR
maximum 50k data
Found 772 of ic50 data for polymerid = 3387,7016
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073989(1,1,1-Trifluoro-7-phenyl-heptan-2-one | 1,1,1-Trif...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073989(1,1,1-Trifluoro-7-phenyl-heptan-2-one | 1,1,1-Trif...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50262188(1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one | CH...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073974(1,1,1-Trifluoro-8-phenyl-octan-2-one | 1,1,1-Trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073974(1,1,1-Trifluoro-8-phenyl-octan-2-one | 1,1,1-Trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073977(1,1,1-Trifluoro-nonan-2-one | 1,1,1-trifluorononan...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073977(1,1,1-Trifluoro-nonan-2-one | 1,1,1-trifluorononan...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570550(CHEMBL4849361)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50466752(CHEMBL4281138)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23316(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23316(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM182852(US9149492, Compound 1D)
Affinity DataIC50:  3.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM182851(US9149492, Compound 1C)
Affinity DataIC50:  3.60nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50163190(2,2,2-Trifluoro-1-phenyl-ethanone | CHEMBL293277)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM182849(US9149492, Compound 1A)
Affinity DataIC50:  4.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570552(CHEMBL4855755)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50372373(CHEMBL261172)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073987(1,1,1-Trifluoro-9-phenyl-nonan-2-one | 1,1,1-trifl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50161525(1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073987(1,1,1-Trifluoro-9-phenyl-nonan-2-one | 1,1,1-trifl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50161520(1-(oxazolo[4,5-b]pyridin-2-yl)-8-phenyloctan-1-one...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570551(CHEMBL4853637)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50371964(CHEMBL273139)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50371961(CHEMBL270373)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570549(CHEMBL4853742)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50462683(CHEMBL4247249)
Affinity DataIC50:  7nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50466740(CHEMBL4282905)
Affinity DataIC50:  9nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50262305(1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one | CH...)
Affinity DataIC50:  10nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50161524(7-Phenyl-1-(5-pyridin-3-yl-[1,3,4]oxadiazol-2-yl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50051894(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073985(1,1,1-Trifluoro-undecan-2-one | 1,1,1-trifluoround...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50073985(1,1,1-Trifluoro-undecan-2-one | 1,1,1-trifluoround...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50163153(1,1,1-Trifluoro-3-phenyl-propan-2-one | CHEMBL2924...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Triacylglycerol hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM182850(US9149492, Compound 1B)
Affinity DataIC50:  10.3nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570558(CHEMBL4849436)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50371970(CHEMBL89506)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570555(CHEMBL4868014)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50372372(CHEMBL272038)
Affinity DataIC50:  16nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50371964(CHEMBL273139)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant carboxylesterase 1 after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kowa

Curated by ChEMBL
LigandPNGBDBM50360307(CHEMBL449307)
Affinity DataIC50:  20nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50204493(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Affinity DataIC50:  20nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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