Compile Data Set for Download or QSAR
maximum 50k data
Found 1414 of ic50 data for polymerid = 3744
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156398(US9018381, 21)
Affinity DataIC50:  0.5nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156403(US9018381, 26 | US9248140, 26)
Affinity DataIC50:  0.5nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156380(US9018381, 4 | US9248140, 4)
Affinity DataIC50:  0.800nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156384(US9018381, 7 | US9248140, 7)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156400(US9018381, 23 | US9248140, 23)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataIC50:  1nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156376(US9018381, 1 | US9248140, 1)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156377(US9018381, 2 | US9248140, 2)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156378(US9018381, 3 | US9248140, 3)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156382(US9018381, 5 | US9248140, 5)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156407(US9018381, 30 | US9248140, 30)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156385(US9018381, 8 | US9248140, 8)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156386(US9018381, 9 | US9248140, 9)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156387(US9018381, 10 | US9248140, 10)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156392(US9018381, 15 | US9248140, 15)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156393(US9018381, 16 | US9248140, 16)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156394(US9018381, 17 | US9018381, 18 | US9248140, 18)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156397(US9018381, 20)
Affinity DataIC50:  1nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of biotinylated BIM BH3 26-mer peptide binding to GST-tagged Bcl-xL (unknown origin) pre-incubated for 30 mins followed by peptide additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50066761(CHEMBL3400497)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156383(US9018381, 6 | US9248140, 6)
Affinity DataIC50:  2nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156394(US9018381, 17 | US9018381, 18 | US9248140, 18)
Affinity DataIC50:  2nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156405(US9018381, 28 | US9248140, 28)
Affinity DataIC50:  2nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156402(US9018381, 25 | US9248140, 25)
Affinity DataIC50:  2nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156401(US9018381, 24 | US9248140, 24)
Affinity DataIC50:  2nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50339781(CHEMBL1689143 | N-(7-{4-[2-(4-Chloro-phenyl)-5,5-d...)
Affinity DataIC50:  3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50:  3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50339777((R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)pipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156399(US9018381, 22 | US9248140, 22)
Affinity DataIC50:  3nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50339783(CHEMBL1689145 | N-(7-{4-[2-(4-Chloro-phenyl)-5,5-d...)
Affinity DataIC50:  3nMAssay Description:Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaSCREEN competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156388(US9018381, 11 | US9248140, 11)
Affinity DataIC50:  3nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156389(US9018381, 12 | US9248140, 12)
Affinity DataIC50:  3nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50388993(CHEMBL2063896)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM611859(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (4-((6-(...)
Affinity DataIC50:  4nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50020936(CHEMBL3287299)
Affinity DataIC50:  4nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50448452(CHEMBL3126119)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427827(CHEMBL2325769)
Affinity DataIC50:  4.5nMAssay Description:Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM156378(US9018381, 3 | US9248140, 3)
Affinity DataIC50:  4.5nMAssay Description:Displacement of synthetic peptide tracer conjugated to fluorescein isothiocyanate from C-terminal 6xHis-tagged Bcl-xL (1 to 209 residues) (unknown or...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50519613(CHEMBL4557431)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of Bcl-xL (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427825(CHEMBL2325771)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427815(CHEMBL2325760)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50393831(CHEMBL2159740)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50388984(CHEMBL2063884)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50393831(CHEMBL2159740)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50388989(CHEMBL2063892)
Affinity DataIC50:  4.90nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM232444(US9346795, 258)
Affinity DataIC50:  4.96nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 55 μl prepared from additions of Biotin-Bcl-xL (Bcl-x...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50393834(CHEMBL2159734)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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