Compile Data Set for Download or QSAR
maximum 50k data
Found 24 of ic50 data for polymerid = 50004156,50004211
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50343721(3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphen...)
Affinity DataIC50:  130nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50343722(3-(4-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(2...)
Affinity DataIC50:  240nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  280nMAssay Description:Inhibition of COX-1 in human whole blood assessed as reduction in thromboxane B2 production by immunoassayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant COX-1 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant COX-1 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50513906(CHEMBL4549769)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of ovine COX1 preincubated for 5 mins followed by arachidonic acid addition and measured after 2 mins by colorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of ovine COX1 preincubated for 5 mins followed by arachidonic acid addition and measured after 2 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326826(2-(4-acetamido)phenyl)-8-benzoyl-quinoline-4-carbo...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50300870(2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxyli...)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326828(8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515745(CHEMBL4474644)
Affinity DataIC50:  1.78E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326827(2-(4-acetamido)phenyl)-6-benzoyl-quinoline-4-carbo...)
Affinity DataIC50:  2.18E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  2.43E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326829(6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50:  2.44E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  2.73E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50524076(CHEMBL4483707)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in prostaglandin E2 production incubated for 10 mins before arachidonic acid addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515744(CHEMBL4441570)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515743(CHEMBL4448990)
Affinity DataIC50:  3.99E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326830(2-(4-azido)phenyl)-8-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50:  6.56E+4nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM13063(4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sul...)
Affinity DataIC50:  9.62E+4nMAssay Description:Inhibition of ovine cyclooxygenase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50326831(2-(4-azido)phenyl)-6-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of sheep COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50589148(CHEMBL5187847)
Affinity DataIC50:  1.15E+5nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Ovis aries)
Y. B. Chavan College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50229774(CHEMBL254418 | N-Hydroxy-4-(5-methyl-3-phenylisoxa...)
Affinity DataIC50:  1.57E+5nMAssay Description:Inhibition of ovine cyclooxygenase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed