Affinity DataKd: 2.20E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 9.00E+4nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 1.50E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 2.44E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 2.50E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 2.70E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
Affinity DataKd: 80nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
Affinity DataKd: 4.80E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
Affinity DataKd: 8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 0.0360nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair
Affinity DataKd: 0.392nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair
Affinity DataKd: 0.257nMAssay Description:Binding affinity to human MDM2 by by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 0.0380nMAssay Description:Binding affinity to human MDM2 by by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 0.0450nMAssay Description:Binding affinity to human MDM2 by by surface plasmon resonace spectroscopyMore data for this Ligand-Target Pair
Affinity DataKd: 800nMAssay Description:Binding affinity to human MDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.30nMAssay Description:Inhibition of human MDM2 L33E mutant (14 to 111 residues) by ITC methodMore data for this Ligand-Target Pair
Affinity DataKd: 219nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.77E+4nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to human MDM2 by temperature dependent fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 75nMAssay Description:Binding affinity to Hdm2More data for this Ligand-Target Pair
Affinity DataKd: 75nMAssay Description:Binding affinity to Hdm2More data for this Ligand-Target Pair
Affinity DataKd: 0.400nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 67nMAssay Description:Binding affinity to human HDM2More data for this Ligand-Target Pair
Affinity DataKd: 2.90nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.150nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.70nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.400nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.0450nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.81E+4nMAssay Description:Binding affinity to MDM2 (25 to 109 amino acids) (unknown origin) after 30 mins by surface plasmon resosnance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 2.65E+4nMAssay Description:Binding affinity to MDM2 (25 to 109 amino acids) (unknown origin) after 30 mins by surface plasmon resosnance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 25nMAssay Description:Binding affinity to MDM2 (25 to 109 amino acids) (unknown origin) after 30 mins by surface plasmon resosnance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding affinity to human MDM2More data for this Ligand-Target Pair
Affinity DataKd: 700nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
Affinity DataKd: 80nMAssay Description:Displacement of fluorescein-labeled p53 peptide from HDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.80E+3nMAssay Description:Displacement of fluorescein-labeled p53 peptide from HDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 37.8nMAssay Description:Antagonist activity at MDM2 (residues 25 to 109) assessed as inhibition of binding to immobilized p53 (residues 15 to 29) preincubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Antagonist activity at MDM2 (residues 25 to 109) assessed as inhibition of binding to immobilized p53 (residues 15 to 29) preincubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataKd: 0.450nMAssay Description:Antagonist activity at MDM2 (residues 25 to 109) assessed as inhibition of binding to immobilized p53 (residues 15 to 29) preincubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataKd: 0.220nMAssay Description:Antagonist activity at MDM2 (residues 25 to 109) assessed as inhibition of binding to immobilized p53 (residues 15 to 29) preincubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Antagonist activity at MDM2 (residues 25 to 109) assessed as inhibition of binding to immobilized p53 (residues 15 to 29) preincubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataKd: 0.400nMAssay Description:Binding affinity to human MDM2 by surface plasmon resonance binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibition of p53 binding to MDM2 (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 8.60nMAssay Description:Inhibition of p53 binding to MDM2 (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Inhibition of p53 binding to MDM2 (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 6.30nMAssay Description:Inhibition of p53 binding to MDM2 (unknown origin) after 30 mins by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 346nMAssay Description:Cross Resistance (antiviral activity) of the compound with L100I (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolatefrom cytopathic...More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Agonist activity at human beta-2 adrenergic receptor expressed in human H292 cells assessed as accumulation of intracellular cAMP after 1 hr by Alpha...More data for this Ligand-Target Pair