BindingDB PrimarySearch_ki

Found 46 of kd data for polymerid = 50007752,5625

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM228654((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87))

Kd: 110nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50575304(CHEMBL4877313)

Kd: 5.10E+3nMAssay Description:Binding affinity to TNF (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50356920(CHEMBL1915761)

Kd: 17nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50021397(CHEMBL3289608)

Kd: 1.82E+3nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)

Kd: 200nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)

Kd: 790nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50021401(CHEMBL3289609)

Kd: 13nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50021402(Ganoderic Acid D)

Kd: 19nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50356915(GANODERIC ACID B)

Kd: 8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50359040(CHEMBL1922174)

Kd: 8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50359037(CHEMBL602899)

Kd: 8nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50359044(CHEMBL1922178)

Kd: 2.45nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50021403(Ganoderic Acid F)

Kd: 2.69nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 3.81nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 1.30E+4nMAssay Description:Binding affinity to TNFMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 1.18E+4nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 9.77E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 8.30E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 6.18E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 5.36E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 8.44E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 5.75E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 7.51E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 7.34E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 5.70E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solventMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50525149(CHEMBL4457006)

Kd: 9.36E+4nMAssay Description:Binding affinity to human TNFalpha by surface plasmon resonance analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50545753(CHEMBL4649816)

Kd: 1.96E+4nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Kd for TNF-alpha-TNFR1 binding at 100 ...More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50545753(CHEMBL4649816)

Kd: 4.26E+3nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Kd for TNF-alpha-TNFR1 binding at 10 u...More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50373071(CHEMBL255489)

Kd: 9.17E+4nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by MST assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50545753(CHEMBL4649816)

Kd: 8.21E+4nMAssay Description:Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by MST assayMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566079(CHEMBL4793685)

Kd: 6.00E+4nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566080(CHEMBL4783333)

Kd: 2.70E+3nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566081(CHEMBL4778232)

Kd: 74nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566082(CHEMBL4779359)

Kd: 2.40nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM3787(1-Phenylbenzimidazole deriv. 4 | 1-benzyl-1H-1,3-b...)

Kd: 3.00E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566083(CHEMBL4777805)

Kd: 1.06E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566084(CHEMBL1507048)

Kd: 3.25E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566085(CHEMBL4779860)

Kd: 1.90E+4nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566086(CHEMBL4793441)

Kd: 1.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566087(CHEMBL4787790)

Kd: 7.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50566088(CHEMBL4793924)

Kd: 6.80nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM56191(MLS000063267 | SMR000074865 | [1-(2,5-dimethylbenz...)

Kd: 2.20E+4nMAssay Description:Binding affinity to human TNF measured after 6 mins by surface plasmon resonanceMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50552392(CHEMBL4743779)

Kd: 13nMAssay Description:Binding affinity to human TNF measured after 2 hrs by surface plasmon resonanceMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50575321(CHEMBL4851618)

Kd: 4.40E+3nMAssay Description:Binding affinity to TNF (unknown origin)More data for this Ligand-Target Pair

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Tumor necrosis factor(Homo sapiens (Human))
Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College

PNG

BDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)

Kd: 9.00E+3nMpH: 7.0Assay Description:Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...More data for this Ligand-Target Pair

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Filter my 46 hits

Targets 1▿
- Tumor necrosis factor 46
Publications 9▿
- Eur J Med Chem 83: 294-306 (2014) 12
- J Med Chem 64: 417-429 (2021) 11
- ACS Med Chem Lett 4: 137-41 (2013) 11
- J Med Chem 63: 8146-8156 (2020) 4
- J Med Chem 64: 17496-17510 (2021) 2
- J Biol Chem 289: 12457-66 (2014) 2
- J Med Chem 63: 15494-15507 (2020) 2
- Nature 450: 1001-1009 (2007) 1
- J Med Chem 62: 5370-5381 (2019) 1
Institutions 9▿
- The Second People'S Hospital Of Fujian Provinc 12
- The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.) 11
- Abbvie 11
- Huazhong University Of Science And Technology 4
- Philochem 2
- Novartis Institutes For Biomedical Research 2
- Institute Of Hematology And Blood Diseases Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College 2
- Shanghai Jiaotong University School Of Medicine 1
- University Of California San Francisco 1
Affinity: 1.3 to 3.3E+5 nM▿
- Kd 46
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 0
Catalog Cmpds: 17