Compile Data Set for Download or QSAR
maximum 50k data
Found 881 of ki data for polymerid = 3619
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093582(CHEMBL3585782)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093587(CHEMBL3585777)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093588(CHEMBL3585776)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093589(CHEMBL3585775)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093581(CHEMBL3585783)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093583(CHEMBL3585781)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093597(CHEMBL3585784)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093585(CHEMBL3585779)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271367(CHEMBL489454 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271367(CHEMBL489454 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093586(CHEMBL3585778)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.0260nMAssay Description:Inhibitory activity against human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM10597((1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{...)
Affinity DataKi:  0.0260nM ΔG°:  -60.4kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM10597((1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{...)
Affinity DataKi:  0.0260nM ΔG°:  -60.4kJ/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50200340((+/-)-huprine Y-HCl | (+/-)-huprineY hydrochloride...)
Affinity DataKi:  0.0330nMAssay Description:Binding affinity to human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50093584(CHEMBL3585780)
Affinity DataKi:  0.0380nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | Tacrine Dimer 4a | methylbis[3-(1,2...)
Affinity DataKi:  0.0600nM ΔG°:  -58.3kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271469(CHEMBL507174 | N-Allyl-N-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  0.0850nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50067482(6-[(2-Methoxy-benzyl)-methyl-amino]-hexanoic acid ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition constant determined against Acetylcholinesterase (AChE) receptor.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271470(CHEMBL499224 | N-(2-Hydroxyethyl)-N-(1,2,3,4-tetra...)
Affinity DataKi:  0.119nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50262988(CHEMBL1200541 | N-(2-chlorobenzyl)-2-(2-(2-((2-chl...)
Affinity DataKi:  0.120nM ΔG°:  -56.6kJ/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataKi:  0.132nMAssay Description:Mixed inhibition of recombinant human AChE expressed in HEK293 cells assessed as dissociation constant for enzyme-inhibitor complex using varying lev...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271471(1,4-bis[3-(1,2,3,4-Tetrahydroacridin-9-yl)aminopro...)
Affinity DataKi:  0.136nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271468(CHEMBL490060 | N-Ethyl-N-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  0.162nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271325(CHEMBL451277 | N-{4-[(1,2,3,4-Tetrahydroacridin-9-...)
Affinity DataKi:  0.223nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50005192(CHEMBL3099497)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50560224(CHEMBL4751100)
Affinity DataKi:  0.258nMAssay Description:Mixed inhibition of recombinant human AChE expressed in HEK293 cells assessed as dissociation constant for enzyme-substrate-inhibitor complex using v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50606822(CHEMBL5219123)
Affinity DataKi:  0.261nMAssay Description:Binding affinity to human AChE assessed as inhibition constant using acetylthiocholine iodide as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50606823(CHEMBL5218804)
Affinity DataKi:  0.264nMAssay Description:Binding affinity to AChE (unknown origin) assessed as inhibition constant using acetylthiocholine iodide as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50389383(CHEMBL2064464)
Affinity DataKi:  0.318nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex using acetylthiocholine substrate prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50389383(CHEMBL2064464)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161477(CHEMBL3785269)
Affinity DataKi:  0.450nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50555835(CHEMBL4752175)
Affinity DataKi:  0.456nMAssay Description:Noncompetitive inhibition of human acetylcholinesterase assessed as affinity towards free enzyme using acetylthiocholine iodide as substrate measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | Tacrine Dimer 4a | methylbis[3-(1,2...)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM8968(2-{bis[3-(1,2,3,4-tetrahydroacridin-9-ylamino)prop...)
Affinity DataKi:  0.650nM ΔG°:  -52.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.670nMAssay Description:Binding affinity to human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161487(CHEMBL3786516)
Affinity DataKi:  0.670nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50556952(CHEMBL4754487)
Affinity DataKi:  0.680nMAssay Description:Mixed-type inhibition of recombinant human AChE assessed as inhibition constant using acetylthiocholine iodide as substrate by Cornish-Bowden plot an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50138279(CHEMBL3752467)
Affinity DataKi:  0.720nMAssay Description:Mixed-type inhibition of recombinant human AChE using acetylthiocholine iodide as substrate assessed as enzyme-inhibitor complex by Lineweaver-Burk d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161485(CHEMBL3786719)
Affinity DataKi:  0.720nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50271473(2,6-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  0.768nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50005193(CHEMBL3099496)
Affinity DataKi:  0.780nMAssay Description:Inhibition of human acetylcholine esteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161479(CHEMBL3786448)
Affinity DataKi:  0.830nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50556952(CHEMBL4754487)
Affinity DataKi:  0.940nMAssay Description:Mixed-type inhibition of recombinant human AChE assessed as dissociation constant for protein-substrate-compound complex using acetylthiocholine iodi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161491(CHEMBL3786651)
Affinity DataKi:  0.980nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataKi:  1nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM10516(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-amine | C...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50138279(CHEMBL3752467)
Affinity DataKi:  1nMAssay Description:Mixed-type inhibition of recombinant human AChE using acetylthiocholine iodide as substrate assessed as enzyme-substrate-inhibitor complex by Linewea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161486(CHEMBL3787502)
Affinity DataKi:  1.10nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Agriibrahim£E£En University

Curated by ChEMBL
LigandPNGBDBM50161478(CHEMBL3787223)
Affinity DataKi:  1.10nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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