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Report error Found 4 Enz. Inhib. hit(s) for PDB: 3PP1
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50337926((R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50337926((R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
LigandPNGBDBM50337926((R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50: <5nMpH: 7.3 T: 25°CAssay Description:Reaction product is determined quantitatively by fluorescent polarization using progressive IMAP beads from Molecular Devices.More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50337926((R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of MEK1 in human COLO205 cellsMore data for this Ligand-Target Pair