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Report error Found 2 Enz. Inhib. hit(s) for PDB: 1NVS
TargetSerine/threonine-protein kinase Chk1(Human)
Glaxosmithkline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 7.4 T: 37°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Human)
Glaxosmithkline

LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Chk1 mediated phosphorylation of cdc25CChecked by AuthorMore data for this Ligand-Target Pair