Found 6 Enz. Inhib. hit(s) for PDB: 2O9I TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataIC50: 40nM EC50: 13nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
3D Structure (crystal)TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataEC50: 120nMAssay Description:Agonist activity at VP16-fused human PXR expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataEC50: 36nMAssay Description:Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataEC50: 8nMAssay Description:Transactivation of PXR in human HepG2 cells by receptor transactivation assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataEC50: 36nMAssay Description:Agonist activity at PXR (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataEC50: 270nMAssay Description:Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
